Adipogen/Z-VAD-FMK (Cell permeable)/AG-CP3-0002-M005/5 mg
商品编号：
AG-CP3-0002-M005
品牌：
Adipogen Inc
市场价：
¥11600.00
美元价：
6960.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Z-VAD(OMe)-FMK;Z-Val-Ala-DL-Asp(OMe)-FMK;pan-CaspaseInhibitor |
| ProductType | Chemical |
| Properties | |
| Formula | C22H30FN3O7 |
| MW | 467.5 |
| Sequence | Z-Val-Ala-DL-Asp(OMe)-fluoromethylketone |
| CAS | 187389-52-2and634911-81-2 |
| PurityChemicals | ≥95%(HPLC) |
| Appearance | Whitesolid. |
| Solubility | SolubleinDMSO,acetonitrileordimethylformamide. |
| OtherProductData | Preparea10mMstocksolutionofthecaspaseinhibitorinhighqualityDMSO.Add2μlofstocksolutionto1mlofculturemediumcontainingcellstogive20μMfinalconcentration.Effectivefinalconcentrationsareestimatedtobe5-20μM.Ifaparticularinhibitorisappliedathigherconcentrations,specificityforanindividualcaspaseorevenforthecaspasefamily(>100μM)mightbecompromised.DMSOconcentrationsabove0.2%maycausecellulartoxicity,thusmaskingtheeffectofthecaspaseinhibitor.Forinvivoexperimentsextending12to48hours,freshinhibitormayhavetobeadded(injected)duetoinactivationbyreactionwithcysteineprotease. |
| InChiKey | MIFGOLAMNLSLGH-SXUUOERCBK |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/StABIlity | Stableforatleast3yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Cellpermeable,non-selectivebroad-spectrumcaspaseinhibitor[1,3,7,8].BindsirreversIBLytothecatalyticsiteofcaspaseproteases[1].
- ThepeptideisO-methylatedintheP1positiononasparticacid,providingenhancedstabilityandincreasedcellpermeability[1].
- InhibitsICE-familyprotease/caspaseprocessing,leADIngtoapoptosisandautophagyinduction[2-4,6,9].
- Decreasesproteasomeactivity[5].
- Potentinhibitorofcaspase-1activationinNLRP3/NALP3-inducedcells[10].
- Usedinapoptosisandinflammasomestudies.
ProductReferences
- Benzyloxycarbonyl-Val-Ala-Asp(OMe)fluoromethylketone(Z-VAD.FMK)inhibitsapoptosisbyblockingtheprocessingofCPP32:E.A.Slee,etal.;Biochem.J.315,21(1996)
- Differentinterleukin-1betaconvertingenzyme(ICE)familyproteaserequirementsfortheapoptoticdeathofTlymphocytestriggeredbydiversestimuli:A.Sarin,etal.;J.Exp.Med.184,2445(1996)
- Processing/activationofatleastfourinterleukin-1betaconvertingenzyme-likeproteasesoccursduringtheexecutionphaseofapoptosisinhumanmonocytictumorcells:M.MacFarlane,etal.;J.CellBiol.137,469(1997)
- Processing/activationofcaspases,-3and-7and-8butnotcaspase-2,intheinductionofapoptosisinB-chroniclymphocyticleukemiacells:D.King,etal.;Leukemia12,1553(1998)
- Proteasomeactivitiesdecreaseduringdexamethasone-inducedapoptosisofthymocytes:J.Beyette,etal.;Biochem.J.332,315(1998)
- JNK(c-JunN-terminalkinase)andp38activationinreceptor-mediatedandchemically-inducedapoptosisofT-cells:differentialrequirementsforcaspaseactivation:M.MacFarlane,etal.;Biochem.J.348,93(2000)
- Statin-inducedproinflammatoryresponseinmitogen-activatedperipheralbloodmononuclearcellsthroughtheactivationofcaspase-1andIL-18secretioninmonocytes:W.R.Coward,etal.;J.Immunol.176,5284(2006)
- Broad-spectrumcaspaseinhibitors:frommythtoreality?D.Chauvier,etal.;CellDeathDiffer.14,387(2007)
- Acalpain-likeproteaseinhibitsautophagiccelldeath:D.T.Madden,etal.;Autophagy3,519(2007)
- MalarialhemozoinisaNalp3inflammasomeactivatingdangersignal;C.Dostert,etal.;PLoSOne4,e6510(2009)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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