![Adipogen/Z-Leu-Leu-Leu-CHO [MG-132]/AG-CP3-0011-M025/25 mg](https://www.ebiomall.cn/images/adipogen/ag-cp3-0011.png)
Adipogen/Z-Leu-Leu-Leu-CHO [MG-132]/AG-CP3-0011-M025/25 mg
商品编号：
AG-CP3-0011-M025
品牌：
Adipogen Inc
市场价：
¥3300.00
美元价：
1980.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Z-LLL-CHO;Carbobenzoxy-L-leucyl-L-leucyl-L-leucinal;MG132 |
| ProductType | Chemical |
| Properties | |
| Formula | C26H41N3O5 |
| MW | 475.6 |
| Sequence | Z-Leu-Leu-Leu-aldeyhde |
| CAS | 133407-82-6 |
| RTECS | OH2824610 |
| PurityChemicals | ≥97%(HPLC) |
| Appearance | Whitesolid. |
| Solubility | SolubleinDMSOorethanol. |
| InChiKey | TZYWCYJVHRLUCT-VABKMULXSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Potent,cellpermeableandselective,reversIBLeproteasomeinhibitor[2,7].
- Blocksdegradationofshort-livedproteinsandinducesaheatshockresponse[2,6,7].
- NF-κBactivationinhibitorthroughIκBdegradation[3,8].
- Cellpermeable,reversiblepeptidealdehydeinhibitor.Calpainandcathepsininhibitor[4,11].
- Hasanticancerpropertiesbyinducingcellcyclearrestandactivatingapoptosisinvariouscancercelllines[8,9,12,13,15].
- Hasadjuvant/chemosensitizerpotential[8].
- NeuriteoutgrowthstimulatorinPC12cells[1].
- Preventsβ-secretasecleavage[5,10].
- Autophagyactivator[12,14].
ProductReferences
- IsolationandcharacterizationofpossibletargetproteinsresponsibleforneuriteoutgrowthinducedbyatripeptidealdehydeinPC12Hcells:Y.Saito,etal.;BBRC184,419(1992)
- InhibitorsoftheproteasomeblockthedegradationofmostcellproteinsandthegenerationofpeptidespresentedonMHCclassImolecules:K.L.Rock,etal.;Cell78,761(1994)
- Theubiquitin-proteasomepathwayisrequiredforprocessingtheNF-kappaB1precursorproteinandtheactivationofNF-kappaB:V.J.Palombella,etal.;Cell78,773(1994)
- Differentialinhibitionofcalpainandproteasomeactivitiesbypeptidylaldehydesofdi-leucineandtri-leucine:S.Tsubuki,etal.;J.Biochem.119,572(1996)
- Thecarboxylterminiofbeta-amyloidpeptides1-40and1-42aregeneratedbydistinctgamma-secretaseactivities:H.Klafki,etal.;J.Biol.Chem.271,28655(1996)
- Proteasomeinhibitionleadstoaheat-shockresponse,inductionofendoplasmicreticulumchaperones,andThermotolerance:K.T.Bush,etal.;J.Biol.Chem.272,9086(1997)
- Proteasomeinhibitors:valuablenewtoolsforcellBIOLOGists:D.H.Lee&A.L.Goldberg;TrendsCellBiol.8,397(1998)
- InhibitionofNF-kappaBsensitizeshumanpancreaticcarcinomacellstoapoptosisinducedbyetoposide(VP16)ordoxorubicin:A.Arlt,etal.;Oncogene20,859(2001)
- PotentialoftheproteasomalinhibitorMG-132asananticanceragent,aloneandincombination:D.Banerjee&A.Liefshitz;AnticancerRes.21,3941(2001)
- Theproteaseinhibitor,MG132,blocksmaturationoftheamyloidprecursorproteinSwedishmutantpreventingcleavagebybeta-Secretase:M.L.Steinhilb,etal.;J.Biol.Chem.276,4476(2001)
- TheproteasomeinhibitorMG132protectsagainstacutepancreatitis:T.Letoha,etal.;FreeRADIc.Biol.Med.39,1142(2005)
- Inductionofautophagybyproteasomeinhibitorisassociatedwithproliferativearrestincoloncancercells:W.K.Wu,etal.;BBRC374,258(2008)
- Synthesis,radiosynthesis,andbiologicalevaluationofnewproteasomeinhibitorsinatumortargetingapproach:M.Vivier,etal.;J.Med.Chem.51,1043(2008)
- Mechanismsofcross-talkbetweentheubiquitin-proteasomeandautophagy-lysosomesystems:V.I.Korolchuk,etal.;FEBSLett.584,1393(2010)
- MG132,aproteasomeinhibitor,inducesapoptosisintumorcells:N.Guo&Z.Peng;AsiaPac.J.Clin.Oncol.9,6(2013)
- AQP2AbundanceisRegulatedbytheE3-LigaseCHIPViaHSP70:M.Centrone,etal.;CellPhysiol.Biochem.44,515(2017)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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