脂肪原/YM-254890/AG-CN2-0509-MC05/500µg
商品编号：
AG-CN2-0509-MC05
品牌：
Adipogen Inc
市场价：
¥4000.00
美元价：
2400.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | QS3666A |
| ProductType | Chemical |
| Properties | |
| Formula | C46H69N7O15 |
| MW | 960.1 |
| CAS | 568580-02-9 |
| Source/HostChemicals | IsolatedfromChromobacteriumsp.QS3666strain. |
| PurityChemicals | ≥95%(HPLC) |
| Appearance | Off-whitesolid. |
| Solubility | SolubleinDMSO(10mg/ml). |
| Declaration | NotsoldinJapan |
| InChiKey | QVYLWCAYZGFGNF-WBWCVGBTSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Cyclicdepsipeptidecomposedofuniqueaminoacidsdifferingfromnormalaminoacids.
- Membranepermeable,potentandselectiveGαqfamilyinhibitor.
- InhibitsthesignaltransductionofGαq,Gα11andGα14(IC50=0.095μM)byblockingtheexchangeofGDPforGTP,preventingtheactivationoftheGprotein.
- InhibitsplateletaggregationinducedbyADP.
- ShowntoinhibitGαq-coupledGPCRsignalingbyinhibitingcalciummobilizationandtohaveantithromboticandthrombolyticeffects.
- Mightbeusedasastartingpointfornewapproachesincancerdrugdiscovery.
- Gαqsignalinghasbeenshowntoregulatebrown/beigeADIpocytesusingthestructurallysimilarspecificGαqfamilyinhibitorFR900359.Itissuggestedthatinhibitionofthispathwaymaybeanoveltherapeuticapproachtocombatobesity.
- ThecloselyrelatedcompoundsYM-254890andFR900359(UBO-QIC)arebothpotentandselectiveGαqfamilyinhibitorsandwereforlongtimeonlyrestrictedaccessIBLe.ThecommercialavailabilityofYM-254890mightgivefurtherinsightsintoGαqfamilysignalingprocesses.
ProductReferences
- YM-254890,anovelplateletaggregationinhibitorproducedbyChromobacteriumsp.QS3666:M.Taniguchi,etal.;J.Antibiot.56,358(2003)
- AnovelGalphaq/11-selectiveinhibitor:J.Takasaki,etal.;J.Biol.Chem.279,47438(2004)
- PharmacologicalpropertiesofYM-254890,aspecificG(alpha)q/11inhibitor,onthrombosisandneointimaformationinmice:T.Kawasaki,etal.;Thromb.Haemost.94,184(2005)
- EffectofYM-254890,aspecificG(alpha)q/11inhibitor,onexperimentalperipheralarterialdiseaseinrats:T.Uemura,etal.;Eur.J.Pharmacol.536,154(2006)
- StructuralbasisforthespecificinhibitionofheterotrimericGqproteinbyasmallmolecule:A.Nishimura,etal.;PNAS107,13666(2010)
- Totalsynthesisandstructure-activityrelationshipstudiesofaseriesofselectiveGproteininhibitors:X.F.Xiong,etal.;Nat.Chem.8,1035(2016)
- Structure,Function,Pharmacology,andTherapeuticPotentialoftheGProtein,Gα/q,11:D.Kamato,etal.;Front.Cardiovasc.Med.2,14(2015)(Review)
- TotalsynthesisofthecyclicdepsipeptideYM-280193,aplateletaggregationinhibitor:H.Kaur,etal.;Org.Lett.17,492(2015)
- Gaqproteins:molecularpharmacologyandtherapeuticpotential:D.Kamato,etal.;Cell.Mol.LifeSci.(Epubaheadofprint)(2016)(Review)
- TheGqsignallingpathwayinhibitsbrownandbeigeadiposetissue:K.Klepac,etal.;Nat.Commun.7,10895(2016)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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