Adipogen/YC-1/AG-CR1-0120-M025/25 mg
商品编号：
AG-CR1-0120-M025
品牌：
Adipogen Inc
市场价：
¥5200.00
美元价：
3120.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 3-(5"-Hydroxymethyl-2"-furyl)-1-benzylindazole |
| ProductType | Chemical |
| Properties | |
| Formula | C19H16N2O2 |
| MW | 304.4 |
| CAS | 170632-47-0 |
| PurityChemicals | ≥98%(NMR) |
| Appearance | Whitetopaleyellowpowder. |
| Solubility | SolubleinDMSO,methanolordichloromethane. |
| Identity | Determinedby1H-NMR. |
| InChiKey | OQQVFCKUDYMWGV-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat+4°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Nitricoxide(NO)independent,superoxide-sensitivesolubleguanylylcyclase(sGC)activator[1,4].
- Inducesconcentration-dependentincreaseincGMPlevels[1,4].
- Inhibitsplateletadhesiontocollagen[2,8].
- Thombosisinhibitor[3].
- Non-specificphosphodiesteraseinhibitor[5].
- Na+channelblocker[6,9].
- Anticancercompound[7,8].
- HIF-αinhibitor[7,10].
- Blocksangiogenesis.Tumorgrowthinhibitor[7,10].
- Apoptosisinducer[11].
- NKcelldifferentiationenhancer[12].
- TRAILsensitizer[13].
ProductReferences
- YC-1,anovelactivatorofplateletguanylatecyclase:F.N.Ko,etal.;Blood84,4226(1994)
- YC-1inhibitedhumanplateletaggregationthroughNO-independentactivationofsolubleguanylatecyclase:C.C.Wu,etal.;Br.J.Pharmacol.116,1973(1995)
- YC-1,anitricoxide-independentactivatorofsolubleguanylatecyclase,inhibitsplatelet-richthrombosisinmice:C.M.Teng,etal.;Eur.J.Pharmacol.320,161(1997)
- MechanismofYC-1-inducedactivationofsolubleguanylylcyclase:A.Friebe&D.Koesling;Mol.Pharmacol.53,123(1998)
- BAY41-2272activatestwoisoformsofnitricoxide-sensitiveguanylylcyclase:M.Koglin,etal.;BBRC292,1057(2002)
- SolubleguanylylcyclaseactivatorYC-1protectswhitematteraxonsfromnitricoxidetoxicityandmetabolicstress,probablythroughNa(+)channelinhibition:G.Garthwaite,etal.;Mol.Pharmacol.61,97(2002)
- YC-1:apotentialanticancerdrugtargetinghypoxia-inducIBLefactor1:E.J.Yeo,etal.;J.Natl.CancerInst.95,516(2003)
- VersatilepharmacologicalactionsofYC-1:anti-platelettoanticancer:Y.S.Chun,etal.;CancerLett.207,1(2004)(Review)
- ANovelDrugBindingSiteonVoltage-GatedSodiumChannelsinRatBrain:D.R.Riddall,etal.;Mol.Pharmacol.69,278(2006)
- PreclinicalevaluationofYC-1,aHIFinhibitor,forthepreventionoftumorspreADIng:D.H.Shin,etal.;CancerLett.255,107(2007)
- YC-1inducesapoptosisofhumanrenalcarcinomaA498cellsinvitroandinvivothroughactivationoftheJNKpathway:S.Y.Wu,etal.;Br.J.Pharmacol.155,505(2008)
- YC-1enhancesnaturalkillercelldifferentiationfromhematopoieticstemcells:S.Yun,etal.;Int.Immunopharmacol.10,481(2010)
- NovelHTSstrategyidentifiesTRAIL-sensitizingcompoundsactingspecificallythroughthecaspase-8apoptoticaxis:D.Finlay,etal.;PLoSOne5,e13375(2010)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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