Adipogen/Y-27632 . dihydrochloride/AG-CR1-3564-M005/5 mg
商品编号：
AG-CR1-3564-M005
品牌：
Adipogen Inc
市场价：
¥1600.00
美元价：
960.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | (R)-(+)-trans-4-(1-Aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamidedihydrochloride |
| ProductType | Chemical |
| Properties | |
| Formula | C14H21N3O.2HCl |
| MW | 247.3.72.9 |
| CAS | 129830-38-2|146986-50-7(freebase) |
| PurityChemicals | ≥98%(HPLC) Containsapprox.1.4%water. |
| Appearance | Whitetopaleyellowsolid. |
| Solubility | Solubleinwater,DMSO(25mg/ml)ormethanol(25mg/ml). |
| Identity | Determinedby1H-NMR. |
| InChiKey | IYOZTVGMEWJPKR-VOMCLLRMSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afterreconstitution,preparealiquotsandstoreat-20°C. Keepunderinertgas. Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. Stocksolutionsarestableforatleast3monthswhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Potent,cellpermeable,selectiveandATP-competitiveRho-associatedproteinkinasesinhibitor,includingp160ROCK,ROCK-IIandPRK2inhibitor[1,3-5].
- Tumorcellinvasionandmetastasissuppressor[2,15].
- Smoothmusclerelaxant[1,6].
- Decreasesliverfibrosisbyhepaticstellatecellgrowthinhibition[7,8].
- Antinociceptive[9].
- Blocksgenerationofinflammatorycytokines[10].
- Stemcellresearchmodulator[11-14,16].
- Preventsapoptosisandenhancesthesurvivalandcloningefficiencyofdissociatedhumanembryonicstem(hES)cellswithoutaffectingtheirpluripotency.IncreasessurvivalrateofhEScellsundergoingcryopreservation[11-14,16].
ProductReferences
- CalciumsensitizationofsmoothmusclemediatedbyaRho-associatedproteinkinaseinhypertension:M.Uehata,etal.;Nature389,990(1997)
- AnessentialpartforRho-associatedkinaseinthetranscellularinvasionoftumorcells:K.Itoh,etal.;Nat.Med.5,221(1999)
- UseandpropertiesofROCK-specificinhibitorY-27632:S.Narumiya,etal.;Meth.Enzymol.325,273(2000)
- Specificityandmechanismofactionofsomecommonlyusedproteinkinaseinhibitors:S.P.Davies,etal.;Biochem.J.351,95(2000)
- PharmacologicalpropertiesofY-27632,aspecificinhibitorofrho-associatedkinases:T.Ishizaki,etal.;Mol.Pharmacol.57,976(2000)
- Y-27632potentiatesrelaxanteffectsofbeta2-adrenoceptoragoNISTsinbovinetrachealsmoothmuscle:T.Nakahara,etal.;Eur.J.Pharmacol.389,103(2000)
- Ap160ROCK-specificinhibitor,Y-27632,attenuatesrathepaticstellatecellgrowth:H.Iwamoto,etal.;J.Hepatol.32,762(2000)
- InhibitionofintrahepaticmetastasisofhumanhepatocellularcarcinomabyRho-associatedproteinkinaseinhibitorY-27632:M.Takamura,etal.;Hepatology33,577(2001)
- Rho-kinaseinhibitor,Y-27632,hasanantinociceptiveeffectinmice:K.Buyukafsar,etal.;Eur.J.Pharmacol.541,49(2006)
- NovelRhokinaseinhibitorswithanti-inflammatoryandvasodilatoryactivities:C.Doe,etal.;JPET320,89(2007)
- AROCKinhibitorpermitssurvivalofdissociatedhumanembryonicstemcells:K.Watanabe,etal.;Nat.Biotechnol.25,681(2007)
- TheROCKinhibitorY-27632enhancesthesurvivalrateofhumanembryonicstemcellsfollowingcryopreservation:X.Li,etal.;StemCellsDev.17,1079(2008)
- EffectofRho-associatedkinase(ROCK)inhibitorY-27632onthepost-thawviabilityofcryopreservedhumanbonemarrow-derivedmesenchymalstemcells:B.C.Heng;TissueCell 41,376(2009)
- EffectofROCKinhibitorY-27632onnormalandvarianthumanembryonicstemcells(hESCs)invitro:itsbenefitsinhESCexpansion:K.Gauthaman,etal.;StemCellRev.6,86(2010)
- PharmacologicalinhibitionofRho-kinasesignalingwithY-27632blocksmelanomatumorgrowth:A.Routhier,etal.;Oncol.Rep.23,861(2010)
- TheROCKinhibitorY-27632improvesrecoveryofhumanembryonicstemcellsafterfluorescence-activatedcellsortingwithmultiplecellsurfaceMarkers:N.Emre,etal.;PLoSOne5,e12148(2010)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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