Adipogen/WY-14643/AG-CR1-3566-M250/250 mg
商品编号：
AG-CR1-3566-M250
品牌：
Adipogen Inc
市场价：
¥5600.00
美元价：
3360.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Pirinixicacid;NSC310038;BRN0759945;((4-Chloro-6-((2,3-dimethylphenyl)amino)-2-pyrimidinyl)thio)aceticacid |
| ProductType | Chemical |
| Properties | |
| Formula | C14H14ClN3O2S |
| MW | 323.8 |
| CAS | 50892-23-4 |
| RTECS | AG2915000 |
| PurityChemicals | ≥98% |
| Appearance | Off-whitesolid. |
| Solubility | Solubleinethanol,DMSO,dimethylformamideorPBS(pH7.2). |
| InChiKey | NSHPHXHGRHSMIK-WAXGXQFOSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Potentperoxisomeproliferator-activatedreceptor(PPARα)activator[1,2,7,9].ActivatesalsoPPARγ[4,7]butnotPPARδ[8].
- Potentanti-hypercholesterolemicagent[1].
- Hypolipidemiccompound.Lipogenesisinducer[2,10].
- Tumorpromoter[2,3,5,15].
- Causesincreasedcellproliferationanddecreasedapoptosis[5].
- Anti-inflammatory.InhibitsNF-κBtranscriptionalactivityanddecreasestheinflammatoryresponsebyreducingtheproductionofinflammatorycytokines(TNF-α,IL1β).Reducesoxidativestress[6,7,12,13].
- Increasesfattyacidoxidation[11].
- Directlyaffectsinsulinsignaling.Increasesglucoseuptake[12].
- Reviews[5,11,14].
ProductReferences
- Apotentantihypercholesterolemicagent:(4-chloro-6-(2,3-xylidino)-2-pyrimidinylthio)aceticacid(Wy-14643):A.A.Santilli,etal.;Experientia30,1110(1974)
- Thehepaticeffectsofhypolipidemicdrugs(clofibrate,nafenopin,tibricacid,andWy-14,643)onhepaticperoxisomesandperoxisome-associatedenzymes:D.E.Moody&J.K.Reddy;Am.J.Pathol.90,435(1978)
- Peroxisomeproliferationandhepatocarcinogenesis:M.S.Rao&J.K.Reddy;Carcinogenesis 8,631(1987)
- Identificationofanewmemberofthesteroidhormonereceptorsuperfamilythatisactivatedbyaperoxisomeproliferatorandfattyacids: A.Schmidt, etal.;Mol.Endocrinol. 6, 1634(1992)
- Non-genotoxichepatocarcinogenesis:suppressionofapoptosisbyperoxisomeproliferators:R.A.Roberts;Ann.N.Y.Acad.Sci.804,588(1996)(Review)
- ThePPARα-leukotrieneB4pathwaytoinflammationcontrol:P.R.Devchand, etal.;Nature 384, 39 (1996)
- Peroxisomeproliferator-activatedreceptorsaandgareactivatedbyindomethacinandothernon-steroidalanti-inflammatorydrugs:J.M.Lehmann,etal.; J.Biol.Chem. 272, 3406(1997)
- Hypolipidemicdrugs,polyunsaturatedfattyacids,andeicosanoidsareligandsforperoxisomeproliferator-activatedreceptorsalphaanddelta:B.M.Forman,etal.;PNAS94,4312(1997)
- Activationofhumanaorticsmooth-musclecellsisinhibitedbyPPARαbutnotbyPPARγactivators:B.Staels,etal.;Nature 393, 790 (1998)
- Influenceofperoxisomeproliferator-activatedreceptoralphaagoNISTsontheintracellularturnoverandsecretionofapolipoprotein(Apo)B-100andApoB-48:D.Lindén,etal.;J.Biol.Chem.277,23044(2002)
- Peroxisomeproliferator-activatedreceptoralpha(PPARalpha)signalinginthegeneregulatorycontrolofenergymetabolisminthenormalanddiseasedheart:B.N.Finck&D.P.Kelly;J.Mol.CellCardiol.34,1249(2002)(Review)
- WY-14643and9-cis-retinoicacidinduceIRS-2/PI3-kinasesignallingpathwayandincreaseglucosetransportinhumanskeletalmusclecells:differentialeffectinmyotubesfromhealthysubjectsandType2diabeticpatients:K.Bouzakri,etal.;Diabetologia47,1314(2004)
- Oxidativestressandinflammatoryresponseevokedbytransientcerebralischemia/reperfusion:effectsofthePPAR-alphaagonistWY14643:M.Collino,etal.;FreeRADIc.Biol.Med.41,579(2006)
- Cardiovascularactionsoftheperoxisomeproliferator-activatedreceptor-alpha(PPARalpha)agonistWy14,643:P.Zahradka;Cardiovasc.DrugRev.25,99(2007)(Review)
- PPARalpha:mechanismofspeciesdifferencesandhepatocarcinogenesisofperoxisomeproliferators;F.J.Gonzalez&Y.M.Shah;Toxicology246,2(2008)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
联络我们
