Adipogen/Wortmannin/AG-CN2-0023-M025/25 mg
商品编号：
AG-CN2-0023-M025
品牌：
Adipogen Inc
市场价：
¥4400.00
美元价：
2640.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | KY12420;BRN0067676;NSC627609;AntibioticSL-2052 |
| ProductType | Chemical |
| Properties | |
| Formula | C23H24O8 |
| MW | 428.4 |
| MerckIndex | 14:10053 |
| CAS | 19545-26-7 |
| RTECS | CB9641000 |
| Source/HostChemicals | IsolatedfromPenicilliumsp. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSOmethanol,ethanolorchloroform.Slightlysolubleinwater. |
| InChiKey | QDLHCMPXEPAAMD-QAIWCSMKSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Antibiotic[1].
- Potentanti-neutrophilagentwithcardioprotectiveeffects[1,13].
- mTOR,DNA-PK,phosphatidylinositol4-kinases,myosinlightchainkinase(MLCK)andmitogen-activatedproteinkinase(MAPK)inhibitorathighconcentrations[2,5,14].
- Potentcellpermeableandselectiveinhibitorofphosphatidyl-inositol3-kinase(PI3K)[3,4].
- SimilarpotencyinvitrofortheclassI,II,andIIIPI3K.
- Antitumorcompound.[6]RADIosensitizingagent[8].
- Adipogenesisinhibitor[5,7].Angiogenesisinhibitor.[10]
- Autophagyinhibitor, regardlessofthenutrientstatusandthusisamoresuitableautophagyinhibitorthan3-MA [12,18].
- DNArepair,receptor-mediatedendocytosisandcellproliferationinhibitor[8,9,14].
- PotentiatestheLPS-inducednitricoxide(NO)productionfrommacrophages[11].
- InducesinvivoAlzheimer-likehyperphosphorylationintau[15].
- Polo-likekinasefamilyinhibitor[16].
- TRAILsensitizer[19]
ProductReferences
- DemethoxyviridinandwortmanninblockphospholipaseCandDactivationinthehumanneutrophil:R.W.Bonser,etal.;Br.J.Pharmacol. 103,1237(1991)
- Wortmannin,amicrobialproductinhibitorofmyosinlightchainkinase:S.Nakanishi,etal.;J.Biol.Chem. 267,2157(1992)
- Wortmanninisapotentphosphatidylinositol3-kinaseinhibitor:theroleofphosphatidylinositol3,4,5-trisphosphateinneutrophilresponses:A.Arcaro&M.P.Wyman;Biochem.J. 296,297(1993)
- Wortmannin,apotentandselectiveinhibitorofphosphatidylinositol-3-kinase:G.Powis,etal.;CancerRes.54,2419(1994)
- Wortmannininhibitstheeffectsofinsulinandserumontheactivitiesofglycogensynthasekinase-3andmitogen-activatedproteinkinase:G.I.Welsh,etal.;Biochem.J.303,15(1994)
- Invitroandinvivoantitumoractivityofthephosphatidylinositol-3-kinaseinhibitor,wortmannin:R.M.Schultz,etal.;AnticancerRes.15,1135(1995)
- Wortmannin,aspecificphosphatidylinositol3-kinaseinhibitor,inhibitsadipocyticdifferentiationof3T3-L1cells:K.Tomiyama,etal.;BBRC 212,263(1995)
- Thephosphatidylinositol3-kinaseinhibitorwortmanninsensitizesmurinefibroblastsandhumantumorcellstoradiationandblocksinductionofp53followingDNAdamage:B.D.Price&M.B.Youmell;CancerRes.56,246(1996)
- WortmanninisapotentinhibitorofDNAdoublestrandbreakbutnotsinglestrandbreakrepairinChinesehamsterovarycells:S.Boulton,etal.;Carcinogenesis17,2285(1996)
- Potentinhibitionofangiogenesisbywortmannin,afungalmetabolite:T.Oikawa&M.Shimamura;Eur.J.Pharmacol.318,93(1996)
- Wortmannin,aspecificinhibitorofphosphatidylinositol-3-kinase,enhancesLPS-inducedNOproductionfrommurineperitonealmacrophages:Y.C.Park,etal.;BBRC 240,692(1997)
- Thephosphatidylinositol3-kinaseinhibitorswortmanninandLY294002inhibitautophagyinisolatedrathepatocytes:E.F.Blommaart,etal.;Eur.J.Biochem. 243,240(1997)
- Wortmannin,apotentantineutrophilagent,exertscardioprotectiveeffectsinmyocardialischemia/reperfusion:L.H.Young,etal.;J.Pharmacol.Exp.Ther.295,37(2000)
- DNA-PKinhibitorwortmanninenhancesDNAdamageinducedbybleomycininV79Chinesehamstercells:N.G.Oliveira,etal.;Teratog.Carcinog.Mutagen.22,343(2002)
- Alzheimer-liketauphosphorylationinducedbywortmannininvivoanditsattenuationbymelatonin:S.J.Liu&J.Z.Wang;ActaPharmacol.Sin. 23,183(2002)
- Wortmannin,awidelyusedphosphoinositide3-kinaseinhibitor,alsopotentlyinhibitsmammalianpolo-likekinase:Y.Liu,etal.;Chem.Biol.12,99(2005)
- ChemistryandBIOLOGyofwortmannin:P.Wipf&R.J.Halter;Org.Biomol.Chem. 3,2053(2005)
- Dualroleof3-methyladenineinmodulationofautophagyviadifferenttemporalpatternsofinhibitiononclassIandIIIphosphoinositide3-kinase:YT.Wu,etal.;J.Biol.Chem.285,10850(2010)
- NovelHTSstrategyidentifiesTRAIL-sensitizingcompoundsactingspecificallythroughtheCaspase-8apoptoticaxis:D.Finlay,etal.;PLoSOne5,e13375(2010)
- InsulininhibitsAMPKactivityandphosphorylatesAMPKSer485/491throughAktinhepatocytes,myotubesandincubatedratskeletalmuscle:R.J.Valentine,etal.;Arch.Biochem.Biophys.562,62(2014)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
联络我们
