脂肪原/汉黄芩素/AG-CN2-0064-M025/25毫克
商品编号：
AG-CN2-0064-M025
品牌：
Adipogen Inc
市场价：
¥4400.00
美元价：
2640.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | WOG;5,7-Dihydroxy-8-methoxyflavone;BRN0287152 |
| ProductType | Chemical |
| Properties | |
| Formula | C16H12O5 |
| MW | 284.3 |
| CAS | 632-85-9 |
| RTECS | LK8331000 |
| Source/HostChemicals | IsolatedfromScutellariabaicalensisGeorgi. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Yellowsolid. |
| Solubility | SolubleinDMSOandmethanol. |
| Identity | Determinedby1H-NMRandMS. |
| InChiKey | XLTFNNCXVBYBSX-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Anti-inflammatory.Increasesnitricoxide(NO)production[1].
- InhibitsPGE2,cyclooxygenase-2(COX-2)andinducIBLenitricoxidesynthase(iNOS;NOSII)[2,5].
- Antioxidant[3].
- Anti-viral.Showsanti-hepatitisBvirusactivity[4].
- MCP-1inhibitor[6].
- ShowsanxiolyticeffectthroughmodulationoftheGABA(A)receptorcomplex[7].
- Antifungal[8].
- Neuroprotective[9].
- Anticancercompound.Apoptosisandcellcyclearrestinducer[10,12,14,17,18].
- SensitizesTNFα-andTRAIL-inducedapoptosis[11,12].
- Antiangiogenic[13].
- NF-κBinhibitor[15].
- Telomeraseactivityinhibitor[16].
- CDK9inhibitor[19].
- PI3K-AKTpathwaymodulator[20].
- Autophagyinducer[21].
ProductReferences
- Inhibitoryeffectsofbaicaleinandwogoninonlipopolysaccharide-inducednitricoxideproductioninmacrophages:I.Wakabayashi;Pharmacol.Toxicol.84,288(1999)
- WogonininhibitsinducibleprostaglandinE(2)productioninmacrophages:I.Wakabayashi&K.Yasui;Eur.J.Pharmacol.406,477(2000)
- AntioxidantandfreerADIcalscavengingeffectsofbaicalein,baicalinandwogonin:D.E.Shieh,etal.;AnticancerRes.20,2861(2000)
- Anti-hepatitisBviruseffectsofwogoninisolatedfromScutellariabaicalensis:R.L.Huang,etal.;PlantaMed.66,694(2000)
- Wogonin,baicalin,andbaicaleininhibitionofinduciblenitricoxidesynthaseandcyclooxygenase-2geneexpressionsinducedbynitricoxidesynthaseinhibitorsandlipopolysaccharide:Y.C.Chen,etal.;Biochem.Pharmacol.61,1417(2001)
- Chineseherbalremedywogonininhibitsmonocytechemotacticprotein-1geneexpressioninhumanendothelialcells:Y.L.Chang,etal.;Mol.Pharmacol.60,507(2001)
- Anxiolyticeffectofwogonin,abenzodiazepinereceptorligandisolatedfromScutellariabaicalensisGeorgi:K.M.Hui,etal.;Biochem.Pharmacol.64,1415(2002)
- Antifungalactivityofwogonin:M.Pal,etal.;Phytother.Res.17,1215(2003)
- Neuroprotectiveeffectofwogonin:potentialrolesofinflammatorycytokines:H.Z.Piao,etal.;Arch.Pharm.Res.27,930(2004)
- TheanticanceractivitiesofwogonininmurinesarcomaS180bothinvitroandinvivo:W.Wang,etal.;Biol.Pharm.Bull.29,1132(2006)
- WogoninsensitizesresistantmalignantcellstoTNFalpha-andTRAIL-inducedapoptosis:S.C.Fas,etal.;Blood108,3700(2006)
- Roleofp53,PUMA,andBaxinwogonin-inducedapoptosisinhumancancercells:D.H.Lee,etal.;Biochem.Pharmacol.75,2020(2008)
- WogoninsuppressestumorgrowthinvivoandVEGF-inducedangiogenesisthroughinhibitingtyrosinephosphorylationofVEGFR2:N.Lu,etal.;LifeSci.82,956(2008)
- WogonininduceddifferentiationandG1phasearrestofhumanU-937leukemiacellsviaPKCdeltaphosphorylation:H.W.Zhang,etal.;Eur.J.Pharmacol.591,7(2008)
- Wogonininhibitsmicroglialcellmigrationviasuppressionofnuclearfactor-kappaBactivity:H.Z.Piao,etal.;Int.Immunopharmacol.8,1658(2008)
- Wogonin,anactivecompoundinScutellariabaicalensis,inducesapoptosisandreducestelomeraseactivityintheHL-60leukemiacells:S.T.Huang,etal.;Phytomedicine17,47(2010)
- WogonininducesapoptosisbyactivationofERKandp38MAPKssignalingpathwaysandgenerationofreactiveoxygenspeciesinhumanbreastcancercells:J.S.Yu&A.K.Kim;Mol.Cells31,327(2011)
- Inhibitoryeffectsofwogoninontheinvasionofhumanbreastcarcinomacellsbydownregulatingtheexpressionandactivityofmatrixmetalloproteinase-9:P.Chen,etal.;Toxicology282,122(2011)
- WogoninandrelatednaturalflavonesareinhibitorsofCDK9thatinduceapoptosisincancercellsbytranscriptionalsuppressionofMcl-1:G.Polier,etal.;CellDeathDis.2,e182(2011)
- Wogonininducesapoptosisanddown-regulatessurvivininhumanbreastcancerMCF-7cellsbymodulatingPI3K-AKTpathway:K.F.Huang,etal.;Int.Immunopharmacol.12,334(2012)
- Wogonininducescross-regulationbetweenautophagyandapoptosisviaavarietyofAktpathwayinhumannasopharyngealcarcinomacells:S.E.Chow,etal.;J.CellBiochem.113,3476(2012)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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