Adipogen/Withaferin A/AG-CN2-0490-M005/5 mg
商品编号：
AG-CN2-0490-M005
品牌：
Adipogen Inc
市场价：
¥4200.00
美元价：
2520.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | NSC101088;NSC273757;5β,6β-Epoxy-4β,22R,27-trihydroxy-1-oxo-δ-lactone-ergosta-2,24-dien-26-oicacid |
| ProductType | Chemical |
| Properties | |
| Formula | C28H38O6 |
| MW | 470.6 |
| MerckIndex | 14:10048 |
| CAS | 5119-48-2 |
| RTECS | KE7288500 |
| Source/HostChemicals | IsolatedfromWithaniasomnifera. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSO(10mg/ml),DMF,100%ethanol(5mg/ml),methanol(5mg/ml)orethylacetate.Insolubleinwater. |
| InChiKey | DBRXOUCRJQVYJQ-KUVJLYTASA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlightwheninsolution. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. Stocksolutionsarestableforatleast3monthswhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Multifunctionalanticancercompound.Amplifiesthecellularantioxidantand/ordetoxificationsystem,suppressesinflammatorypathways,selectivelyinhibitstumorcellproliferationandinducesapoptosis,suppressestumorangiogenesis,blocksepithelial-to-mesenchymaltransition(EMT),tumorinvasionandmetastasis,alterstumorcellmetabolism,inducesimmunomodulationanddownregulatescancerstemcellstargets.
- Sensitizesresistantcancercellstoexistingchemotherapeuticagents.
- Antioxidant.Inducescytoprotectiveenzymes(Nrf2-dependentaswell),includingSOD,HO-1(hemeoxygenase-1),catalase,glutathioneperoxidise,glutathiones-transferaseandNQO1.
- Anti-inflammatoryagent.InhibitsCOX-2andiNOSexpression(atproteinandmRNAlevel)andPGE2production.PreventsNF-κBactivationbyinhibitingactivationofIKKβ.InhibitsHelicobacterpylori-inducedIL-1βproductionbyregulatingNF-κBanddirectlyinhibitingNLRP3inflammasomeactivation.
- Antiproliferativeagent.InducesG2/Mphasecellcyclearrest,targetingCDKs.ShowntomodulateSTAT3,Bcl2,Notchreceptors,Akt,Hsp90,EGFR,HER2andPCNA.
- Disruptstheorganizationofmicrotubulesandactin/MICROFILament.StimulatesF-actincross-linking.
- Inducestumorcellapoptosis.ShowntoinduceROSproduction.ActivatesmitochondrialapoptosispathwaythroughBcl-2downregulationandBaxupregulation.Showntoinducep53-dependentpathwaysandER-stress.ActivatesthetumorsuppressorproteinPAR-4.Directlyorindirectlyinhibitsselectedotherkinases,such MAPKorSTAT3.Showntoinhibithedgehogsignallingpathway.
- Describedtobeanautophagyinducerandinhibitor.
- Potentinhibitorofthe20Sproteasomeβ5subunitchymotrypsin-likeactivity.
- PotentangiogenesisinhibitorbymodulatingVEGF.Antimigratory,antiinvasiveandantimetastaticcompound.TargetsTGF-β,vimentin,MMPsandNotchreceptors.
- Inhibitscancerstemcellstargets,includingaldehydedehydrogenase1(ALDH1)activity.Alterscellline-specificthemRNAexpressionofcancerstemcellMarkers,suchasOct4,SOX-2,andNanog.
- Reportedtoinduceneuronalregeneration.
- Antidiabeticcompound.PotentLeptinsensitizer,actingsimilartoCelastrol(Prod.No.AG-CN2-0460).
ProductReferences
- AntitumoractivityofwithaferinA(NSC-101088):B.Shohat,etal.;CancerChemother.Rep.51,271(1967)
- WithaferinAisapotentinhibitorofangiogenesis:R.Mohan,etal.;Angiogenesis7,115(2004)
- Neuriticregenerationandsynapticreconstructioninducedbywithanolide:A:T.Kuboyama,etal.;Br.J.Pharmacol.144,961(2005)
- ThetumorproteasomeisaprimarytargetforthenaturalanticancercompoundWithaferinAisolatedfrom"Indianwintercherry":H.Yang,etal.;Mol.Pharmacol.71,426(2007)
- ThetumorinhibitorandantiangiogenicagentwithaferinAtargetstheintermediatefilamentproteinvimentin:P.Bargagna-Mohan,etal.;Chem.Biol.14,623(2007)
- WithaferinAinducesapoptosisbyactivatingp38mitogen-activatedproteinkinasesignalingcascadeinleukemiccellsoflymphoidandmyeloidoriginthroughmitochondrialdeathcascade:C.Mandal,etal.;Apoptosis13,1450(2008)
- Inhibitionofmonosodiumuratecrystal-inducedinflammationbywithaferinA:E.P.Sabina,etal.;J.Pharm.Pharm.Sci.11,46(2008)
- WithaferinAtargetsheatshockprotein90inpancreaticcancercells:Y.Yu,etal.;Biochem.Pharmacol.79,542(2010)
- Notch-1inhibitionbyWithaferin-A:atherapeutictargetagainstcoloncarcinogenesis:S.Koduru,etal.;Mol.CancerTher.9,202(2010)
- WithaferinAinhibitsactivationofsignaltransducerandactivatoroftranscription3inhumanbreastcancercells:J.Lee,etal.;Carcinogenesis.31,1991(2010)
- InhibitionoftheNEMO/IKKßassociationcomplexformation,anovelmechanismassociatedwiththeNF-kBactivationsuppressionbyWithaniasomnifera"skeymetabolitewithaferinA:A.Grover,etal.;BMCGenomics11,s25(2010)
- WithaferinAinducesapoptosisinhumanmelanomacellsthroughgenerationofreactiveoxygenspeciesanddown-regulationofBcl-2:E.Mayola,etal.;Apoptosis16,1014(2011)
- Withaferinaaltersintermediatefilamentorganization,cellshapeandbehavior:B.Grin,etal.;PLoSOne7,e39065(2012)
- WithaferinAcausesactivationofNotch2andNotch4inhumanbreastcancercells:J.Lee,etal.;BreastCancerRes.Treat.136,45(2012)
- MolecularinsightinthemultifunctionalactivitiesofWithaferinA:W.VandenBerghe,etal.;Biochem.Pharmacol.84,1282(2012)(Review)
- InhibitionofVEGF:anovelmechanismtocontrolangiogenesisbyWithaniasomnifera"skeymetaboliteWithaferinA:S.Saha,etal.;InSilicoPharmacol.1,11(2013)
- WithaferinAinhibitsNF-kappaBactivationbytargetingcysteine179inIKKß:K.Heyninck,etal.;Biochem.Pharmacol.91,501(2014)
- WithaferinAInhibitsHelicobacterpylori-inducedProductionofIL-1βinDendriticCellsbyRegulatingNF-κBandNLRP3InflammasomeActivation:J.E.Kim,etal.;ImmuneNetw.15,269(2015)
- MoleculardockinganddynamicsimulationstudiesevidencedplausIBLeimmunotherapeuticanticancerpropertybyWithaferinAtargetingindoleamine2,3-dioxygenase:S.V.Reddy,etal.;J.Biomol.Struct.Dyn.33,2695(2015)
- HedgehoginhibitorsfromWithaniasomnifera:T.Yoneyama,etal.;Bioorg.Med.Chem.Lett.25,3541(2015)
- TheUseofWithaferinAtostudyintermediatefilaments:R.Mohan&P.Bargagna-Mohan;MethodsEnzymol.568,187(2016)
- Simultaneousinhibitionoftheubiquitin-proteasomesystemandautophagyenhancesapoptosisinducedbyERstressaggravatorsinhumanpancreaticcancercells:Autophagy12,1521(2016)
- WithaferinAisaleptinsensitizerwithstrongantidiabeticpropertiesinmice:J.Lee,etal.;Nat.Med.22,1023(2016)
- Withaferin-A-Anaturalanticanceragentwithpleitropicmechanismsofaction:I.C.Lee&B.Y.Choi;Int.J.Mol.Sci.17,290(2016)(Review)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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