Adipogen/Wedelolactone/AG-CN2-0424-M005/5 mg
商品编号：
AG-CN2-0424-M005
品牌：
Adipogen Inc
市场价：
¥4200.00
美元价：
2520.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 7-Methoxy-5,11,12-trihydroxy-coumestan;WDL |
| ProductType | Chemical |
| Properties | |
| Formula | C16H10O7 |
| MW | 314.2 |
| CAS | 524-12-9 |
| Source/HostChemicals | IsolatedfromEcliptaprostrata. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Yellowtoambercrystallinepowder. |
| Solubility | SolubleinDMSOormethanol. |
| Identity | Determinedby1H-NMR. |
| InChiKey | XQDCKJKKMFWXGB-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Cellpermeable,selectiveandirreversIBLeIKKαandβkinaseactivityinhibitor[2].
- NF-κBinhibitor.BlocksphosphorylationanddegradationofIκBα[2].
- Antihepatotoxic.5-Lipoxygenase(5-LOX)inhibitor[1,2].
- Anti-inflammatory[2].
- HIV-1integraseinhibitor[3].
- Anticancerandantiproliferativecompound[4,5].
- Modulatesandrogenreceptor(AR)activation[4].
- ApoptosisinducerviadownregulationofPKCε[5,9].
- DNAtopoisomeraseIIαinhibitor[6].
- Gprotein-coupledreceptor-35(GPR35)agoNIST[7].
- InhibitsADIpogenicdifferentiationofmesenchymalstemcells(hAMSCs)throughERKpathway[8].
- STAT1proteindephosphorylationinhibitor[10].
- Antifibrotic[11].
ProductReferences
- Wedelolactoneandcoumestanderivativesasnewantihepatotoxicandantiphlogisticprinciples:S.M.Wong,etal.;Arzneimittelforschung38,661(1988)
- WedelolactonesuppressesLPS-inducedcaspase-11expressionbydirectlyinhibitingtheIKKcomplex:M.Kobori,etal.;CellDeathDiffer.11,123(2004)
- HIV-1proteaseandHIV-1integraseinhibitorysubstancesfromEcliptaprostrata:S.Tewtrakul,etal.;Phytother.Res.21,1092(2007)
- CompoundsfromWedeliachinensissynergisticallysuppressandrogenactivityandgrowthinprostatecancercells:F.M.Lin,etal.;Carcinogenesis28,2521(2007)
- PharmacologicinhibitorsofIkappaBkinasesuppressgrowthandmigrationofmammarycarcinosarcomacellsinvitroandpreventosteolyticbonemetastasisinvivo:A.I.Idris,etal.;Mol.CancerTher.8,2339(2009)
- InhibitionoftopoisomeraseIIα:novelfunctionofwedelolactone:P.Benes,etal.;CancerLett.303,29(2011)
- Anti-inflammatorygallicAcidandwedelolactoneareGprotein-coupledreceptor-35agonists:H.Deng&Y.Fang;Pharmacology89,211(2012)
- WedelolactoneinhibitsadipogenesisthroughtheERKpathwayinhumanadiposetissue-derivedmesenchymalstemcells:S.Lim,etal.;J.CellBiochem.113,3436(2012)
- Wedelolactone,amedicinalplant-derivedcoumestan,inducescaspase-dependentapoptosisinprostatecancercellsviadownregulationofPKCεwithoutinhibitingAkt:S.Sarveswaran,etal.;Int.J.Oncol.41,2191(2012)
- Wedelolactone,anaturallyoccurringcoumestan,enhancesinterferon-γsignalingthroughinhibitingSTAT1proteindephosphorylation:Z.Chen,etal.;J.Biol.Chem.288,14417(2013)
- Wedelolactoneexhibitsanti-fibroticeffectsonhumanhepaticstellatecelllineLX-2:Y.Xia,etal.;Eur.J.Pharmacol.714,105(2013)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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