![Adipogen/VR23 [Proteasome Inhibitor]/AG-CR1-3676-M025/25 mg](https://www.ebiomall.cn/images/adipogen/ag-cr1-3676.png)
Adipogen/VR23 [Proteasome Inhibitor]/AG-CR1-3676-M025/25 mg
商品编号：
AG-CR1-3676-M025
品牌：
Adipogen Inc
市场价：
¥6000.00
美元价：
3600.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 7-Chloro-4-[4-[(2,4-dinitrophenyl)sulfonyl]-1-piperazinyl]quinoline |
| ProductType | Chemical |
| Properties | |
| Formula | C19H16ClN5O6S |
| MW | 477.9 |
| CAS | 1624602-30-7 |
| PurityChemicals | ≥98% |
| Appearance | Whitesolid. |
| Solubility | SolubleinDMSO(10mg/ml)orDMF.Poorlysolubleinaqueoussolutions. |
| OtherProductData | Note:Warmingandsonicationmayberequiredwhendissolvingthecompoundinthesolventofchoice.Stocksolutionsarestableforatleast1monthwhenstoredat-20°C. |
| InChiKey | PDQVZPPIHADUOO-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- PotentselectiveandreversIBLechloroquinederivative20Sproteasomeinhibitor(allproteolyticsubunits).
- Targetsthetrypsin-likeβ2subunitoftheconstitutive20Sproteasome(IC50=1nM).Cross-reactsandinhibitsthechymotrypsin-likeβ5subunit(IC50=50-100nM)andthecaspase-like/peptidyl-glutamylpeptide-hydrolyzing(PGPH)β1subunit(IC50=3μM).
- Anticancercompoundeffectiveincell-basedassaysandagainstmultiplemyelomaandmetastaticbreastcancerinvivo.
- Invitro,inducescellcyclearrestandapoptosisinhumancancercelllinesincludingmultiplemyeloma,aswellasinbortezomib-resistentmultiplemyelomacells,butwithminimaleffectsonnon-cancerouscells.
ProductReferences
- VR23:AQuinoline-SulfonylHybridProteasomeInhibitorThatSelectivelyKillsCancerviaCyclinE-MediatedCentrosomeAmplification:S.Pundir,etal.;CancerRes.75,4164(2015)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
联络我们
