Adipogen/Vorinostat/SYN-3006-M100/100 mg
商品编号：
SYN-3006-M100
品牌：
Adipogen Inc
市场价：
¥1940.00
美元价：
1164.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | SAHA;Suberoylanilidebishydroxamide;Suberoylanilidehydroxamicacid; |
| ProductType | Chemical |
| Properties | |
| Formula | C14H20N2O3 |
| MW | 264.3 |
| CAS | 149647-78-9 |
| PurityChemicals | ≥95% |
| Appearance | Solid. |
| Solubility | SolubleinDMSOorethanol.Almostinsolubleinwater. |
| Identity | Determinedby1H-NMR. |
| Declaration | ManufacturedbySynKinase. |
| OtherProductData | ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| InChiKey | WAEXFXRVDQXREF-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
Vorinostat(SAHA,MK0683,Zolinza)inhibitstheenzymaticactivityofhistonedeacetylasesHDAC1,HDAC2andHDAC3(ClassI)andHDAC6(ClassII)atnanomolarconcentrations(IC50<86=""nm).=""these=""enzymes=""catalyze=""the=""removal=""of=""acetyl=""groups=""from=""the=""lysine=""residues=""of=""histones=""proteins.=""in=""some=""cancer=""cells,=""there=""is=""an=""overexpression=""of=""hdacs,=""or=""an=""aberrant=""recruitment=""of=""hdacs=""to=""oncogenic=""transcription=""factors=""causing=""hypoacetylation=""of=""core=""nucleosomal=""histones.=""by=""inhibiting=""histone=""deacetylase,=""vorinostat=""causes=""the=""accumulation=""of=""acetylated=""histones=""and=""induces=""cell=""cycle=""arrest=""and/or=""apoptosis=""of=""some=""transformed=""cells.=""the=""mechanism=""of=""the=""antineoplastic=""effect=""of=""vorinostat=""has=""not=""been=""fully="">
ProductReferences
- Vorinostat,ahistonedeacetylaseinhibitor,enhancestheresponseofhumantumorcellstoionizingrADIationthroughprolongationofgamma-H2AXfoci:A.Munshi,etal.;Mol.CancerTher.5,1967(2006)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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