Adipogen/Vorinostat/SYN-3006-M050/50 mg
商品编号：
SYN-3006-M050
品牌：
Adipogen Inc
市场价：
¥1520.00
美元价：
912.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | SAHA; Suberoyl anilide bishydroxamide; Suberoylanilide hydroxamic acid; |
| Product Type | Chemical |
| Properties | |
| Formula | C14H20N2O3 |
| MW | 264.3 |
| CAS | 149647-78-9 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO or ethanol. Almost insoluble in water. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | WAEXFXRVDQXREF-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Vorinostat (SAHA, MK0683, Zolinza) inhibits the enzymatic activity of histone deacetylases HDAC1, HDAC2 and HDAC3 (Class I) and HDAC6 (Class II) at nanomolar concentrations (IC50< 86="" nm).="" these="" enzymes="" catalyze="" the="" removal="" of="" acetyl="" groups="" from="" the="" lysine="" residues="" of="" histones="" proteins.="" in="" some="" cancer="" cells,="" there="" is="" an="" overexpression="" of="" hdacs,="" or="" an="" aberrant="" recruitment="" of="" hdacs="" to="" oncogenic="" transcription="" factors="" causing="" hypoacetylation="" of="" core="" nucleosomal="" histones.="" by="" inhibiting="" histone="" deacetylase,="" vorinostat="" causes="" the="" accumulation="" of="" acetylated="" histones="" and="" induces="" cell="" cycle="" arrest="" and/or="" apoptosis="" of="" some="" transformed="" cells.="" the="" mechanism="" of="" the="" antineoplastic="" effect="" of="" vorinostat="" has="" not="" been="" fully="">
Product References
- Vorinostat, a histone deacetylase inhibitor, enhances the response of human tumor cells to ionizing radiation through prolongation of gamma-H2AX foci: A. Munshi, et al.; Mol. Cancer Ther. 5, 1967 (2006)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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