Adipogen/Vinpocetine/AG-CN2-0454-M100/100 mg
商品编号：
AG-CN2-0454-M100
品牌：
Adipogen Inc
市场价：
¥4000.00
美元价：
2400.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | VPC;(3α,16α)-Eburnamenine-14-carboxylicacidethylester;Ethylapovincaminate;RGH-4405;TCV3B;AY27255 |
| ProductType | Chemical |
| Properties | |
| Formula | C22H26N2O2 |
| MW | 350.5 |
| MerckIndex | 14:9991 |
| CAS | 42971-09-5 |
| RTECS | JW4792000 |
| Source/HostChemicals | Semi-syntheticfromVoacangaafricana. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Whitetoslightlyyellowcrystallinepowder. |
| Solubility | SolubleinDMSO,dichloromethane,acetoneor100%ethanol.Insolubleinwater. |
| Identity | Determinedby1H-NMR. |
| InChiKey | DDNCQMVWWZOMLN-IRLDBZIGSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +20°C |
| LongTermStorage | +20°C |
| HandlingAdvice | Protectfromlightandmoisture. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat+20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- SelectiveCa2+-calmodulindependentcGMP-phosphodiesterase(PDE1)inhibitor.Showsvasorelaxantactivity.
- Neuroprotectiveagent.
- Selectivelyinhibitsvoltage-sensitiveNa2+channels
- Potentanti-inflammatoryagent.
- InhibitorofNF-κB-dependentinflammatoryresponsesbydirectlytargetingIKK.
- ShowntoinhibittheNLRP3inflammasome.
- Antioxidant.FreerADIcalscavenger.
- Anticancercompound.
- Anticonvulsant.
- Attenuatesosteoblasticdifferentiationofvascularsmoothmusclecells.
ProductReferences
- Effectsofselectiveinhibitorsoncyclicnucleotidephosphodiesterasesofrabbitaorta:H.S.Ahn,etal.;Biochem.Pharmacol.38,3331(1989)
- RoleofselectivecyclicGMPphosphodiesteraseinhibitioninthemyorelaxantactionsofM&B22,948,MY-5445,vinpocetineand1-methyl-3-isobutyl-8-(methylamino)xanthine:J.E.Souness,etal.;Br.J.Pharmacol.98,725(1989)
- Vinpocetineselectivelyinhibitsneurotransmitterreleasetriggeredbysodiumchannelactivation:M.Sitges&V.Nekrassov;NeuRochem.Res.24,1585(1999)
- Invitroantioxidantpropertiesofpentoxifylline,piracetam,andvinpocetine:B.Horvath,etal.;Clin.Neuropharmacol.25,37(2002)
- EffectsofVinpocetineonmitochondrialfunctionandneuroprotectioninprimarycorticalneurons:K.Tarnok,etal.;Neurochem.Int.53,289(2008)
- Ameliorationofintracerebroventricularstreptozotocininducedcognitivedysfunctionandoxidativestressbyvinpocetine-aPDE1inhibitor:R.Deshmukh,etal.;Eur.J.Pharmacol.620,49(2009)
- VinpocetineinhibitsNF-kappaB-dependentinflammationviaanIKK-dependentbutPDE-independentmechanism:K.I.Jeon,etal.;PNAS107,9795(2010)
- Vinpocetineasapotentantiinflammatoryagent:A.E.Medina,etal.;PNAS107,9921(2010)
- Vinpocetineinhibitsbreastcancercellsgrowthinvitroandinvivo:E.W.Huang,etal.;Apoptosis17,1120(2012)
- Vinpocetineattenuateslipidaccumulationandatherosclerosisformation:Y.Cai,etal.;BBRC434,439(2013)
- Theanti-seizuredrugsvinpocetineandcarbamazepine,butnotvalproicacid,reduceinflammatoryIL-1betaandTNF-alphaexpressioninrathippocampus:C.D.Gomez,etal.;J.Neurochem.130,770(2014)
- Anti-inflammatoryeffectsofvinpocetineinatherosclerosisandischemicstroke:areviewoftheliterature:L.Zhang&L.Yang;Molecules20,335(2014)
- Vinpocetineinhibitsamyloid-betainducedactivationofNF-κB,NLRP3inflammasomeandcytokineproductioninretinalpigmentepithelialcells:R.T.Liu,etal.;Exp.EyeRes.127,49(2014)
- Vinpocetinemodulatesmetabolicactivityandfunctionduringretinalischemia:L.Nivison-Smith,etal.;Am.J.Physiol.CellPhysiol.308,737(2015)
- Vinpocetinereduceslipopolysaccharide-inducedinflammatorypainandneutrophilrecruitmentinmicebytargetingoxidativestress,cytokinesandNF-κB:K.W.Ruiz-Miyazawa,etal.;Chem.Biol.Interact.237,9(2015)
- Vinpocetineattenuatesosteoblasticdifferentiationofvascularsmoothmusclecells:Y.Y.Ma,etal.;PLoSOne11,e0162295(2016)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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