Adipogen/Vincristine . sulfate/AG-CN2-0446-M025/25 mg
商品编号：
AG-CN2-0446-M025
品牌：
Adipogen Inc
市场价：
¥2600.00
美元价：
1560.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | VCR; 22-Oxovincaleukoblastine; NSC 67574; Oncovin; Lilly 37231; Leucristine; Leurocristine; LS-228 |
| Product Type | Chemical |
| Properties | |
| Formula | C46H56N4O10 . H2SO4 |
| MW | 825.0 . 98.1 |
| Merck Index | 14: 9986 |
| CAS | 2068-78-2 |
| RTECS | OH6340000 |
| Source/Host Chemicals | Synthetic. Originally isolated from Vinca rosea. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to light-yellow powder. |
| Solubility | Soluble in water, DMSO or methanol. |
| InChi Key | AQTQHPDCURKLKT-JKDPCDLQSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +20°C |
| Long Term Storage | +4°C |
| Handling Advice | Protect from light and moisture. |
| Use/Stability | Stable for at least 2 years after receipt when stored at +4°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- Immunosuppressant.
- Anticancer compound. Chemotherapeutic agent.
- Depolymerizes microtubules and irreversibly blocks binding of tubulin to microtubule proteins.
- Apoptosis inducer and cell cycle inhibitor in G2/M phase.
- Autophagy inhibitor. Inhibits microtubule-mediated fusion of autophagosome with lysosme.
- Inducer of IL-1β production.
- Activates alone and synergistically together with doxorubicin the NLRP3-inflammasome mediated processing of IL-1β.
- Monoamine oxidase (MAO) inhibitor.
Product References
- Suppression of immune response by Vincristine and Vinblastine: A.C. Aisenberg; Nature 200, 484 (1963)
- Vinblastine and vincristine are inhibitors of monoamine oxidase B: J.K. Son, et al.; J. Med. Chem. 33, 1845 (1990)
- Cell death induced by vincristine in the intestinal crypts of mice and in a human Burkitt's lymphoma cell line: B.V. Harmon, et al.; Cell Prolif. 25, 523 (1992)
- Interaction of vinca alkaloids with tubulin: a comparison of vinblastine, vincristine, and vinorelbine: S. Lobert, et al.; Biochemistry 35, 6806 (1996)
- Antimitotic natural products and their interactions with tubulin: E. Hamel; Med. Res. Rev. 16, 207 (1996)
- Raf-1/bcl-2 phosphorylation: a step from microtubule damage to cell death: M.V. Blagosklonny, et al.; Cancer Res. 57, 130 (1997)
- Tubulin as a target for anticancer drugs: agents which interact with the mitotic spindle: A. Jordan, et al.; Med. Res. Rev. 18, 259 (1998) (Review)
- The effect of antimicrotubule agents on signal transduction pathways of apoptosis: a review: L.G. Wang; Cancer Chemother. Pharmacol. 44, 355 (1999) (Review)
- Vincristine-induced apoptosis in vivo in peripheral blood mononuclear cells of children with acute lymphoblastic leukaemia (ALL): E. Groninger, et al.; Br. J. Haematol. 111, 875 (2000)
- Autophagy-mediated HMGB1 release antagonizes apoptosis of gastric cancer cells induced by vincristine via transcriptional regulation of Mcl-1: Z. Zhan, et al.; Autophagy 8, 109 (2012)
- Autophagy and microtubules - new story, old players: R. Mackeh, et al.; J. Cell Sci. 126, 1071 (2013) (Review)
- Production of IL-1β by bone marrow-derived macrophages in response to chemotherapeutic drugs: synergistic effects of doxorubicin and vincristine: J. Wong, et al.; Cancer Biol. Ther. 15, 1395 (2014)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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