脂肪原/长春新碱。硫酸盐/AG-CN2-0446-M005/5 mg
商品编号：
AG-CN2-0446-M005
品牌：
Adipogen Inc
市场价：
¥800.00
美元价：
480.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | VCR;22-Oxovincaleukoblastine;NSC67574;Oncovin;Lilly37231;Leucristine;Leurocristine;LS-228 |
| ProductType | Chemical |
| Properties | |
| Formula | C46H56N4O10.H2SO4 |
| MW | 825.0.98.1 |
| MerckIndex | 14:9986 |
| CAS | 2068-78-2 |
| RTECS | OH6340000 |
| Source/HostChemicals | Synthetic.OriginallyisolatedfromVincarosea. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Whitetolight-yellowpowder. |
| Solubility | Solubleinwater,DMSOormethanol. |
| InChiKey | AQTQHPDCURKLKT-JKDPCDLQSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +20°C |
| LongTermStorage | +4°C |
| HandlingAdvice | Protectfromlightandmoisture. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat+4°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Immunosuppressant.
- Anticancercompound.Chemotherapeuticagent.
- DepolymerizesmicrotubulesandirreversIBLyblocksbindingoftubulintomicrotubuleproteins.
- ApoptosisinducerandcellcycleinhibitorinG2/Mphase.
- Autophagyinhibitor.Inhibitsmicrotubule-mediatedfusionofautophagosomewithlysosme.
- InducerofIL-1βproduction.
- ActivatesaloneandsynergisticallytogetherwithdoxorubicintheNLRP3-inflammasomemediatedprocessingofIL-1β.
- Monoamineoxidase(MAO)inhibitor.
ProductReferences
- SuppressionofimmuneresponsebyVincristineandVinblastine:A.C.Aisenberg;Nature200,484(1963)
- VinblastineandvincristineareinhibitorsofmonoamineoxidaseB:J.K.Son,etal.;J.Med.Chem.33,1845(1990)
- CelldeathinducedbyvincristineintheintestinalcryptsofmiceandinahumanBurkitt"slymphomacellline:B.V.Harmon,etal.;CellProlif.25,523(1992)
- Interactionofvincaalkaloidswithtubulin:acomparisonofvinblastine,vincristine,andvinorelbine:S.Lobert,etal.;Biochemistry35,6806(1996)
- Antimitoticnaturalproductsandtheirinteractionswithtubulin:E.Hamel;Med.Res.Rev.16,207(1996)
- Raf-1/bcl-2phosphorylation:astepfrommicrotubuledamagetocelldeath:M.V.Blagosklonny,etal.;CancerRes.57,130(1997)
- Tubulinasatargetforanticancerdrugs:agentswhichinteractwiththemitoticspindle:A.Jordan,etal.;Med.Res.Rev.18,259(1998)(Review)
- Theeffectofantimicrotubuleagentsonsignaltransductionpathwaysofapoptosis:areview:L.G.Wang;CancerChemother.Pharmacol.44,355(1999)(Review)
- Vincristine-inducedapoptosisinvivoinperipheralbloodmononuclearcellsofchildrenwithacutelymphoblasticleukaemia(ALL):E.Groninger,etal.;Br.J.Haematol.111,875(2000)
- Autophagy-mediatedHMGB1releaseantagonizesapoptosisofgastriccancercellsinducedbyvincristineviatranscriptionalregulationofMcl-1:Z.Zhan,etal.;Autophagy8,109(2012)
- Autophagyandmicrotubules-newstory,oldplayers:R.Mackeh,etal.;J.CellSci.126,1071(2013)(Review)
- ProductionofIL-1βbybonemarrow-derivedmacrophagesinresponsetochemotherapeuticdrugs:synergisticeffectsofdoxorubicinandvincristine:J.Wong,etal.;CancerBiol.Ther.15,1395(2014)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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