Adipogen/Varenicline tartrate/SYN-3013-M001/1 mg
商品编号：
SYN-3013-M001
品牌：
Adipogen Inc
市场价：
¥1300.00
美元价：
780.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | Chantix; Champix |
| Product Type | Chemical |
| Properties | |
| Formula | C13H13N3 . C4H6O6 |
| MW | 211.3 . 150.1 |
| CAS | 375815-87-5 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO or ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: Nicotinic ACh receptor | Kinase Group: N/A | Substrate: N/A Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | TWYFGYXQSYOKLK-CYUSMAIQSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS | No |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Varenicline is a prescription medication used to treat smoking addiction. It is a partial agonist of the α4/β2 subtype of the nicotinic acetylcholine receptor. In addition, it acts on α3/β4 and weakly on α3β2 and α6-containing receptors. A full agonism was displayed on α7-receptors. It stimulates nicotine receptors weaker than nicotine and is similar to cytisine in this respect and different to the nicotinic antagonist bupropion. In vitro studies demonstrated that varenicline does not inhibit the cytochrome P450 enzymes (IC50 >6400 ng/mL): 1A2, 2A6, 2B6, 2C8, 2C9, 2C19, 2D6, 2E1, and 3A4/5. In human hepatocytes in vitro, varenicline does not induce the cytochrome P450 enzymes 1A2 and 3A4.
Product References
- Varenicline: an alpha4beta2 nicotinic receptor partial agonist for smoking cessation: J.W. Coe, et al.; J. Med. Chem. 48, 3474 (2005)
- Pharmacological profile of the alpha4beta2 nicotinic acetylcholine receptor partial agonist varenicline, an effective smoking cessation aid: H. Rollema, et al.; Neuropharmacol. 52, 985 (2007)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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