脂肪原/熊去氧胆酸/AG-CN2-0411-G001/1克
商品编号：
AG-CN2-0411-G001
品牌：
Adipogen Inc
市场价：
¥800.00
美元价：
480.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | UDCA;USAN;BRN3219888;NSC657950;NSC683769 |
| ProductType | Chemical |
| Properties | |
| Formula | C24H40O4 |
| MW | 392.6 |
| MerckIndex | 14:9889 |
| CAS | 128-13-2 |
| RTECS | FZ2000000 |
| Source/HostChemicals | Synthetic. |
| PurityChemicals | ≥95%(NMR) |
| Appearance | Whitetooff-whitepowder. |
| Solubility | SolubleinDMSO,ethanolordimethylformamide.Sparinglysolubleinwater. |
| Identity | Determinedby1H-NMR. |
| InChiKey | RUDATBOHQWOJDD-UZVSRGJWSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | +4°C |
| HandlingAdvice | Protectfromlight. Protectfrommoisture. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat+4°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Endogenoushydrophilicbileacid.
- Antioxidant.Cytoprotectiveagainstoxidativestressandcelldeath.
- Hepatoprotectiveatcellularandmolecularlevel,includingstabilizationofmembranes.Protectshepatocytesagainstbileacid-inducedapoptosis.
- Antiapoptoticandantinecrotic.Targetsthemitochondrialfunctionandintegrity,reductionofendoplasmaticstressandinteractionswithsurvivalsignalsincAMP,Akt,NF-κB,MAPKandPI3Ksignalingpathways.
- Modulatorandfinetunerofthep53-Mdm-2complex.
- Chemopreventiveagainstcolorectalcancerbycounteringthetumor-promotingeffectsofsecondarybileacids.Showsalsoeffectsonepidermalgrowthfactorreceptor(EGFR)signalingandCOX-2expression.
- Immunomodulatorandanti-inflammatorycompound.ModifiesTLR4andTLR9signalingpathwaysanddownregulatestheproductionofproinflammatorytumornecrosisfactor-α(TNF-α).
- PregnaneXreceptoragoNIST.
- Neuroprotective.Inhibitsneuronalapoptosis.
- GlucocorticoidReceptor(GR)agonist.
- Anticholestaticagent.Usedtoreducecholesterolabsorptionandforcholesterolgallstonedissolution.
- Usedtotreatprimarybiliarycirrhosis(PBC).
- Interfereswiththeprogressionofnon-alcoholicfattyliverdisease(NAFLD)/NASH.
- ReducesCXCR3expression[11].
- TIMP-1inducer[12].
- ADAM17inhibitor[12].
ProductReferences
- Antioxidantpropertiesofursodeoxycholicacid:D.Lapenna,etal.;Biochem.Pharmacol.64,1661(2002)(Review)
- Ursodeoxycholicacidincholestaticliverdisease:mechanismsofactionandtherapeuticuserevisited:G.Paumgartner,etal.;Hepatology36,525(2002)(Review)
- Nonalcoholicfattyliverdisease:anoverviewofcurrentinsightsinpathogenesis,diagnosisandtreatmen.T.C.Schreuder,etal.;WorldJ.Gastroenterol.14,2474(2008)(Review)
- p53andtheregulationofhepatocyteapoptosis:implicationsfordiseasepathogenesis:J.D.Amaral,etal.;TrendsMol.Med.15,531(2009)(Review)
- Bileacids:regulationofapoptosisbyursodeoxycholicacid:J.D.Amaral,etal.;J.Lipid.Res.50,1721(2009)(Review)
- Bileacidsasregulatorsofhepaticlipidandglucosemetabolism:M.Trauner,etal.;Dig.Dis.28,220(2010)(Review)
- Targetingthep53pathwayofapoptosis:J.D.Amaral,etal.;Curr.Pharm.Des.16,2493(2010)(Review)
- Ursodeoxycholicacidandchemopreventionofcolorectalcancer:L.Serfaty,etal.;Gastroenterol.Clin.Biol.34,516(2010)(Review)
- Ursodeoxycholicacidandbile-acidmimeticsastherapeuticagentsforcholestaticliverdiseases:anoverviewoftheirmechanismsofaction:R.Poupon;Clin.Res.Hepatol.Gastroenterol.36,S3(2012)(Review)
- Ursodeoxycholicacidincholestasis:linkingactionmechanismstotherapeuticapplications:M.G.Roma,etal.;Clin.Sci.(Lond).121,523(2011)(Review)
- CXCR3axisinpatientswithprimarybiliarycirrhosis:apossIBLenovelmechanismoftheeffectofursodeoxycholicacid:P.Manousou,etal.;Clin.Exp.Immunol.172,9(2013)
- LiverprotectiveeffectofursodeoxycholicacidincludesregulationofADAM17activity:H.Buryova,etal.;BMCGastroenterol.13,155(2013)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
联络我们
