脂肪原/URMC-099/SYN-1211-M001/1毫克
商品编号：
SYN-1211-M001
品牌：
Adipogen Inc
市场价：
¥2160.00
美元价：
1296.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 3-(1H-Indol-5-yl)-5-(4-(4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridine |
| ProductType | Chemical |
| Properties | |
| Formula | C27H27N5 |
| MW | 421.5 |
| CAS | 1229582-33-5 |
| PurityChemicals | ≥95%(HPLC) |
| Appearance | Solid. |
| Solubility | SolubleinDMSOorwater. |
| Declaration | ManufacturedbySYNkinase. |
| OtherProductData | Target:MLK-3|KinaseGroup:TKL ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| InChiKey | QKKIWEILHCXECO-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/StABIlity | Stableforatleast3yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
Inhibitionofmixedlineagekinase3(MLK-3)isapotentialstrategyforthetreatmentofParkinson"sdiseaseandHIV-1associatedneuro-cognitivedisorders(HAND),requiringaninhibitorthatcanachievesignificantbrainconcentrationlevels.URMC-099isanorallybioavailableMLK-3inhibitorwithexcellentbrainexposureinmousePKmodelsandminimalinterferencewithkeyhumanCYP450enzymesorhERGchannels.URMC-099inhibitsmultiplekinasepathways,includingMLK-3(14nM)andleucine-richrepeatserine/threonine-proteinkinase2(LRRK2)(11nM).
ProductReferences
- Thenewsmall-moleculemixed-lineagekinase3inhibitorURMC-099isneuroprotectiveandanti-inflammatoryinmodelsofhumanimmunodeficiencyvirus-associatedneurocognitivedisorders:D.F.Marker,etal.;J.Neurosci.33,9998(2013)
- Discovery,synthesis,andcharacterizationofanorallybioavailable,brainpenetrantinhibitorofmixedlineagekinase3:V.S.Goodfellow,etal.;J.Med.Chem.56,8032(2013)
- MLK3regulatesfMLP-stimulatedneutrophilmotility:O.Polesskaya,etal.;Mol.Immunol.58,214(2014)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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