Adipogen/Tubastatin A/AG-CR1-3900-M010/10 mg
商品编号：
AG-CR1-3900-M010
品牌：
Adipogen Inc
市场价：
¥1200.00
美元价：
720.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | N-hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]benzamide |
| ProductType | Chemical |
| Properties | |
| Formula | C20H21N3O2 |
| MW | 335.4 |
| CAS | 1252003-15-8 |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Off-whitesolid. |
| Solubility | SolubleinDMSO. |
| Identity | Determinedby1H-NMR. |
| InChiKey | GOVYBPLHWIEHEJ-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- CellpermeablepotentandselectiveclassIIbhistonedeacetylase6(HDAC6)inhibitor(IC50=15nM,>1000-foldselectiveagainstotherHDACsand60-foldforHDAC8).
- Neuroprotective.Effectivelypreventsneuronalcelldeath(by≥95%at10µM)uponoxidativestressinductionbyHCAandselectivelyinducescellularα-tubulin,butnothistoneH4,hyperacetylation(2.5to5µM)inprimaryratcorticalneuroncultures.
- ImprovescognitioninAlzheimer"sdiseasetransgenicmice.
- Exhibitscardioprotectiveandanticancerchemotherapeuticactivities.ReducestumorgrowthandcellproliferationandinducescellcyclearrestinG1.
- InhibitsTNFα(IC50=272nM)andIL-6(IC50=712nM)inLPS-stimulatedhumanTHP-1macrophagesanddisplaysanti-inflammatoryactivityinanimalmodels.
- Antileishmanial.
- HDAC6deacetylatestubulin,HSP90andthecorehistones(H2A,H2B,H3,H4).Histonedeacetylasesactviatheformationoflargemultiproteincomplexes.HDAC6playsanimportantroleinmicrotubule-dependentcellmotility,transcriptionalregulation,degradationofmisfoldedproteinsandcellcycleandisinvolvedinautophagy,inflammation,cancerandneurodegeneration.
ProductReferences
- Rationaldesignandsimplechemistryyieldasuperior,neuroprotectiveHDAC6inhibitor,tubastatinA:K.V.Butler,etal.;JACS132,10842(2010)
- Histonedeacetylase6andheatshockprotein90controlthefunctionsofFoxp3(+)T-regulatorycells:E.F.deZoeten,etal.;Mol.CellBiol.31,2066(2011)
- Second-generationhistonedeacetylase6inhibitorsenhancetheimmunosuppressiveeffectsofFoxp3+T-regulatorycells:J.H.Kalin,etal.;J.Med.Chem.55,639(2012)
- Selectivehistonedeacetylase6inhibitorsbearingsubstitutedurealinkersinhibitmelanomacellgrowth:J.A.Bergman,etal.;J.Med.Chem.55,9891(2012)
- HDAC6inhibitionrestoresciliaryexpressionanddecreasestumorgrowth:S.A.GrADIlone,etal.;CancerRes.73,2259(2013)
- Tubastatin,aselectivehistonedeacetylase6inhibitorshowsanti-inflammatoryandanti-rheumaticeffects:S.Vishwakarma,etal.;Int.Immunopharmacol.16,72(2013)
- HDAC6inhibitionresultsintauacetylationandmodulatestauphosphorylationanddegradationinoligodendrocytes:M.Noack,etal.;Glia62,535(2014)
- Histonedeacetylase6inhibitionimprovesmemoryandreducestotaltaulevelsinamousemodeloftaudeposition:M.L.Selenica,etal.;AlzheimersRes.Ther.6,12(2014)
- TubastatinA/ACY-1215improvescognitioninAlzheimer"sdiseasetransgenicmice:L.Zhang,etal.;J.AlzheimersDis.41,1193(2014)
- Selectiveinhibitorofhistonedeacetylase6(tubastatinA)suppressesproliferationofhepatitisCvirusrepliconincultureofhumanhepatocytes:M.V.Kozlov,etal.;Biochem.79,637(2014)
- Theantileishmanialactivityofisoforms6-and8-selectivehistonedeacetylaseinhibitors:Q.Sodji,etal.;Bioorg.Med.Chem.Lett.24,4826(2014)
- Targetinghistonedeacetylase6mediatesadualanti-melanomaeffect:Enhancedantitumorimmunityandimpairedcellproliferation:K.V.Woan,etal.;Mol.Oncol.9,1447(2015)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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