Adipogen/Troglitazone/AG-CR1-3565-M005/5 mg
商品编号：
AG-CR1-3565-M005
品牌：
Adipogen Inc
市场价：
¥1100.00
美元价：
660.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 5-[[4-[(3,4-Dihydro-6-hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)methoxy]phenyl]methyl]-2,4-thiazolidinedione;Romglizone;BRN4338399;CS-045;CI-991;GR92132X |
| ProductType | Chemical |
| Properties | |
| Formula | C24H27NO5S |
| MW | 441.5 |
| MerckIndex | 14:9769 |
| CAS | 97322-87-7 |
| RTECS | XJ5813130 |
| PurityChemicals | ≥98% |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSO,ethanolordimethylformamide(DMF). |
| InChiKey | GXPHKUHSUJUWKP-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- PotentandselectivePPARγagoNISTwithnoactivationofPPARαandPPARδ[2].
- Anti-diabeticagentwithpotentglucose-loweringeffectsanddecreasinginsulinresistanceinADIposetissues.StimulatesAdipogenesis[1,6,8].
- Apoptosisandcellcyclearrestinducerinseveralcancercelllines[3-8].
- Anti-inflammatory[8-10,12].
- Inhibitsvascularsmoothmusclecell(VSMC)migration[11].
ProductReferences
- CharacterizationofneworalantidiabeticagentCS-045.StudiesinKKandob/obmiceandZuckerfattyrats:T.Fujiwara,etal.;Diabetes37,1549(1988)
- Anantidiabeticthiazolidinedioneisahighaffinityligandforperoxisomeproliferator-activatedreceptorgamma(PPARgamma):J.M.Lehmann,etal.;J.Biol.Chem.270,12953(1995)
- Growthinhibitionofmyeloidleukemiacellsbytroglitazone,aligandforperoxisomeproliferatoractivatedreceptorgamma,andretinoids:H.Asou,etal.;Int.J.Oncol.15,1027(1999)
- Ligandtype-specificinteractionsofperoxisomeproliferator-activatedreceptorgammawithtranscriptionalcoactivators:Y.Kodera,etal.;J.Biol.Chem.275,33201(2000)
- Inhibitionofhumanlungcancercellgrowthbytheperoxisomeproliferator-activatedreceptor-gammaagoniststhroughinductionofapoptosis:Y.Tsubouchi,etal.;BBRC270,400(2000)
- Troglitazoneandrelatedcompounds:therapeuticpotentialbeyonddiabetes:T.Fujiwara&H.Horikoshi;LifeSci.67,2405(2000)
- Troglitazoneinducesapoptosisviathep53andGadd45pathwayinvascularsmoothmusclecells:T.Okura,etal.;Eur.J.Pharmacol.407,227(2000)
- Troglitazoneandrelatedcompounds:therapeuticpotentialbeyonddiabetes:T.Fujiwara&H.Horikoshi;LifeSci. 67,2405(2000)(Review)
- Suppressionofnuclearfactor-kappaBandstimulationofinhibitorkappaBbytroglitazone:evidenceforananti-inflammatoryeffectandapotentialantiatheroscleroticeffectintheobese:H.Ghanim,etal.;J.Clin.Endocrinol.Metab.86,1306(2001)
- Nuclearfactor-kappaBsuppressiveandinhibitor-kappaBstimulatoryeffectsoftroglitazoneinobesepatientswithtype2diabetes:A.Aljada,etal.;evidenceofanantiinflammatoryaction?:J.Clin.Endocrinol.Metab.86,3250(2001)
- Peroxisomeproliferator-activatedreceptor-gammaligandsinhibitnuclearbutnotcytosolicextracellularsignal-regulatedkinase/mitogen-activatedproteinkinase-regulatedstepsinvascularsmoothmusclecellmigration:S.Goetze,etal.;J.Cardiovasc.Pharmacol.38,909(2001)
- Peroxisomeproliferator-activatedreceptorgammaligandssuppressthetranscriptionalactivationofcyclooxygenase-2.Evidenceforinvolvementofactivatorprotein-1andCREB-bindingprotein/p300:K.Subbaramaiah,etal.;J.Biol.Chem. 276,12440(2001)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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