脂肪原/雷公藤甲素/AG-CN2-0448-M010/10 mg
商品编号：
AG-CN2-0448-M010
品牌：
Adipogen Inc
市场价：
¥2700.00
美元价：
1620.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | PG 490; NSC163062 |
| Product Type | Chemical |
| Properties | |
| Formula | C20H24O6 |
| MW | 360.4 |
| CAS | 38748-32-2 |
| RTECS | YK7751000 |
| Source/Host Chemicals | Isolated from Tripterygium sp. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Crystalline solid. |
| Solubility | Soluble in DMSO. Sparingly soluble in ethanol. |
| Identity | Determined by 1H-NMR. |
| InChi Key | DFBIRQPKNDILPW-KTGKZQHOSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Keep under inert gas. Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- Potent immunosuppressant with anti-inflammatory and antitumor properties.
- Exhibits potent antiproliferative activity, induces apoptosis, modulates autophagy and inhibits cell cycle regulators.
- Inhibits global gene transcription by inducing degradation of RNA polymerase II (Pol II) and by inhibiting the ATPase activity of XPB (a subunit of the general transcription factor TFIIH).
- Human dCTP pyrophosphatase 1 inhibitor.
- Interferes with a number of transcription factors including p53, NF-κB, nuclear factor of activated T cells (NFAT) and heat shock factor protein 1 (HSF-1).
- Shown to inhibit aromatase activity.
- Shows antifertility activity and antipolycystic kidney disease effects.
Product References
- Triptolide and tripdiolide, novel antileukemic diterpenoid triepoxides from Tripterygium wilfordii: S.M. Kupchan, et al.; JACS 94, 7194 (1972)
- Triptolide: a potential male contraceptive: Y. Lue, et al.; J. Androl. 19, 479 (1998)
- Triptolide induces apoptotic death of T lymphocyte: Y. Yang, et al.; Immunopharmacology 40, 139 (1998)
- Triptolide: a potent inhibitor of NF-kappa B in T-lymphocytes: H. Liu, et al.; Acta Pharmacol. Sin. 21, 782 (2000)
- Triptolide, a novel immunosuppressive and anti-inflammatory agent purified from a Chinese herb Tripterygium wilfordii Hook F: B.J. Chen; Leuk. Lymphoma 42, 253 (2001) (Review)
- Triptolide inhibits the growth and metastasis of solid tumors: S. Yang, et al.; Mol. Cancer Ther. 2, 65 (2003)
- Triptolide, an inhibitor of the human heat shock response that enhances stress-induced cell death: S.D. Westerheide, et al.; J. Biol. Chem. 281, 9616 (2006)
- Triptolide alters mitochondrial functions: Y. Su, et al.; Adv. Exp. Med. Biol. 599, 139 (2007)
- Triptolide functions as a potent angiogenesis inhibitor: M.F. He, et al.; Int. J. Cancer 126, 266 (2010)
- Triptolide inhibits proliferation and migration of colon cancer cells by inhibition of cell cycle regulators and cytokine receptors: S.M. Johnson, et al.; J. Surg. Res. 168, 197 (2011)
- RNA polymerase - an important molecular target of triptolide in cancer cells: J. Pan; Cancer Lett. 292, 149 (2010) (Review)
- Triptolide induces cell death in pancreatic cancer cells by apoptotic and autophagic pathways: N. Mujumdar, et al.; Gastroenterol. 139, 598 (2010)
- Triptolide and its expanding multiple pharmacological functions: Q. Liu; Int. Immunopharmacol. 11, 377 (2011) (Review)
- XPB, a subunit of TFIIH, is a target of the natural product triptolide: D.V. Titov, et al.; Nat. Chem. Biol. 7, 182 (2011)
- Triptolide directly inhibits dCTP pyrophosphatase: T.W. Corson, et al.; Chembiochem 12, 1767 (2011)
- Triptolide (TPL) inhibits global transcription by inducing proteasome-dependent degradation of RNA polymerase II (Pol II): Y. Wang, et al.; PLoS One 6, e23993 (2011)
- Triptolide: structural modifications, structure-activity relationships, bioactivities, clinical development and mechanisms: Z.L. Zhou, et al.; Nat. Prod. Rep. 29, 457 (2012)
- Effect of triptolide on aromatase activity in human placental microsomes and human placental JEG-3 cells: J. Zhang, et al.; Arzneimittelforschung 61, 727 (2011)
- TAB1: a target of triptolide in macrophages: Y. Lu, et al.; Chem. Biol. 21, 246 (2014)
- Triptolide induces apoptosis of breast cancer cells via a mechanism associated with the Wnt/β-catenin signaling pathway: H. Shao, et al.; Exp. Ther. Med. 8, 505 (2014)
- Triptolide Induces Cell Damage in Lipopolysaccharide (LPS)-Treated Macrophages in an LPS-Signaling Cascade-Dependent Manner: K. Kohama, et al.; J. Cytokine Biol. 2, (2017)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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