Adipogen/Triptolide/AG-CN2-0448-M005/5 mg
商品编号：
AG-CN2-0448-M005
品牌：
Adipogen Inc
市场价：
¥1800.00
美元价：
1080.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | PG490;NSC163062 |
| ProductType | Chemical |
| Properties | |
| Formula | C20H24O6 |
| MW | 360.4 |
| CAS | 38748-32-2 |
| RTECS | YK7751000 |
| Source/HostChemicals | IsolatedfromTripterygiumsp. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Crystallinesolid. |
| Solubility | SolubleinDMSO.Sparinglysolubleinethanol. |
| Identity | Determinedby1H-NMR. |
| InChiKey | DFBIRQPKNDILPW-KTGKZQHOSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Keepunderinertgas. Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Potentimmunosuppressantwithanti-inflammatoryandantitumorproperties.
- Exhibitspotentantiproliferativeactivity,inducesapoptosis,modulatesautophagyandinhibitscellcycleregulators.
- InhibitsglobalgenetranscriptionbyinducingdegradationofRNApolymeraseII(PolII)andbyinhibitingtheATPaseactivityofXPB(asubunitofthegeneraltranscriptionfactorTFIIH).
- HumandCTPpyrophosphatase1inhibitor.
- Interfereswithanumberoftranscriptionfactorsincludingp53,NF-κB,nuclearfactorofactivatedTcells(NFAT)andheatshockfactorprotein1(HSF-1).
- Showntoinhibitaromataseactivity.
- Showsantifertilityactivityandantipolycystickidneydiseaseeffects.
ProductReferences
- Triptolideandtripdiolide,novelantileukemicditerpenoidtriepoxidesfromTripterygiumwilfordii:S.M.Kupchan,etal.;JACS94,7194(1972)
- Triptolide:apotentialmalecontraceptive:Y.Lue,etal.;J.Androl.19,479(1998)
- TriptolideinducesapoptoticdeathofTlymphocyte:Y.Yang,etal.;Immunopharmacology40,139(1998)
- Triptolide:apotentinhibitorofNF-kappaBinT-lymphocytes:H.Liu,etal.;ActaPharmacol.Sin.21,782(2000)
- Triptolide,anovelimmunosuppressiveandanti-inflammatoryagentpurifiedfromaChineseherbTripterygiumwilfordiiHookF:B.J.Chen;Leuk.Lymphoma42,253(2001)(Review)
- Triptolideinhibitsthegrowthandmetastasisofsolidtumors:S.Yang,etal.;Mol.CancerTher.2,65(2003)
- Triptolide,aninhibitorofthehumanheatshockresponsethatenhancesstress-inducedcelldeath:S.D.Westerheide,etal.;J.Biol.Chem.281,9616(2006)
- Triptolidealtersmitochondrialfunctions:Y.Su,etal.;Adv.Exp.Med.Biol.599,139(2007)
- Triptolidefunctionsasapotentangiogenesisinhibitor:M.F.He,etal.;Int.J.Cancer126,266(2010)
- Triptolideinhibitsproliferationandmigrationofcoloncancercellsbyinhibitionofcellcycleregulatorsandcytokinereceptors:S.M.Johnson,etal.;J.Surg.Res.168,197(2011)
- RNApolymerase-animportantmoleculartargetoftriptolideincancercells:J.Pan;CancerLett.292,149(2010)(Review)
- Triptolideinducescelldeathinpancreaticcancercellsbyapoptoticandautophagicpathways:N.Mujumdar,etal.;Gastroenterol.139,598(2010)
- Triptolideanditsexpandingmultiplepharmacologicalfunctions:Q.Liu;Int.Immunopharmacol.11,377(2011)(Review)
- XPB,asubunitofTFIIH,isatargetofthenaturalproducttriptolide:D.V.Titov,etal.;Nat.Chem.Biol.7,182(2011)
- TriptolidedirectlyinhibitsdCTPpyrophosphatase:T.W.Corson,etal.;Chembiochem12,1767(2011)
- Triptolide(TPL)inhibitsglobaltranscriptionbyinducingproteasome-dependentdegradationofRNApolymeraseII(PolII):Y.Wang,etal.;PLoSOne6,e23993(2011)
- Triptolide:structuralmodifications,structure-activityrelationships,bioactivities,clinicaldevelopmentandmechanisms:Z.L.Zhou,etal.;Nat.Prod.Rep.29,457(2012)
- EffectoftriptolideonaromataseactivityinhumanplacentalmicrosomesandhumanplacentalJEG-3cells:J.Zhang,etal.;Arzneimittelforschung61,727(2011)
- TAB1:atargetoftriptolideinmacrophages:Y.Lu,etal.;Chem.Biol.21,246(2014)
- TriptolideinducesapoptosisofbreastcancercellsviaamechanismassociatedwiththeWnt/β-cateninsignalingpathway:H.Shao,etal.;Exp.Ther.Med.8,505(2014)
- TriptolideInducesCellDamageinLipopolysaccharide(LPS)-TreatedMacrophagesinanLPS-SignalingCascade-DependentManner:K.Kohama,etal.;J.CytokineBiol.2,(2017)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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