Adipogen/Trichostatin A/AG-CN2-0108-M001/1 mg
商品编号：
AG-CN2-0108-M001
品牌：
Adipogen Inc
市场价：
¥1600.00
美元价：
960.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | TSA;A300;R-(E,E)-7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptADIenamide |
| ProductType | Chemical |
| Properties | |
| Formula | C17H22N2O3 |
| MW | 302.4 |
| MerckIndex | 14:9649 |
| CAS | 58880-19-6 |
| Source/HostChemicals | IsolatedfromStreptomyceshygroscopicus. |
| PurityChemicals | ≥95%(HPLC) |
| Appearance | Off-whitesolid. |
| Solubility | SolubleinDMSO,ethanol,methanol,dimethylformamide,acetonitrileorchloroform.Insolubleinwaterorhexane. |
| Declaration | ManufacturedbyBiOlinksK.K.withcourtesystrainfromTheKitasatoInstitute. |
| InChiKey | RTKIYFITIVXBLE-QEQCGCAPSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afterreconstitution,preparealiquotsandstoreat-20°C. |
| Use/StABIlity | Stableforatleast3yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Antibiotic[1].
- Antifungal[1].
- Antiprotozoal[2].
- PotentandreversIBLe,cellpermeableinhibitorofhistonedeacetylase(HDAC)[3].
- Immunosuppressive[4,8].
- Anticancercompound[5,6,9,16].
- Antifibrogenic[7,10].
- Apoptosisinducer[9,14,16].
- InducescellgrowtharrestatbothG1andG2/Mphases[11,16].
- EnhancestheefficacyofanticanceragentsthattargetDNA[11].
- Inactivatesmitoticspindlecheckpoint[12].
- Smoothmusclecellproliferationinhibitor[13].
- Telomeraseinhibitor[14].
- DownregulatesDNAmethyltransferaseDNMT1andaffectsDNAmethylation[15].
- Anti-inflammatory[17,19].
- Inhibitsosteoclastogenesisandboneresorption[18].
- Promoteseitherself-renewalordifferentiationofembryonicstemcells[20].
ProductReferences
- Anewantifungalantibiotic,trichostatin:N.Tsuji,etal.;J.Antibiot.(Tokyo)29,1(1976)
- ScreeningfornewantitrichomonalsubstancesofmicrobialoriginandantitrichomonalactivityoftrichostatinA:K.Otoguro,etal.;J.Antibiot.(Tokyo)41,461(1988)
- PotentandspecificinhibitionofmammalianhistonedeacetylasebothinvivoandinvitrobytrichostatinA:M.Yoshida,etal.;J.Biol.Chem.265,17174(1990)
- SelectiveinhibitionofIL-2geneexpressionbytrichostatinA,apotentinhibitorofmammalianhistonedeacetylase:I.Takahashi,etal.;J.Antibiot.(Tokyo)49,453(1996)
- TrichostatinAmodulatesexpressionofp21waf1/cip1,Bcl-xL,ID1,ID2,ID3,CRAB2,GATA-2,hsp86andTFIID/TAFII31mRNAinhumanlungadenocarcinomacells:B.Eickhoff,etal.;Biol.Chem.381,107(2000)
- TrichostatinAisahistonedeacetylaseinhibitorwithpotentantitumoractivityagainstbreastcancerinvivo:D.M.Vigushin,etal.;Clin.CancerRes.7,971(2001)
- TrichostatinA,ahistonedeacetylaseinhibitor,suppressescollagensynthesisandpreventsTGF-beta(1)-inducedfibrogenesisinskinfibroblasts:K.Rombouts,etal.;Exp.CellRes.278,184(2002)
- ThehistonedeacetylaseinhibitorTrichostatinAmodulatesCD4+Tcellresponses:J.M.Moreira,etal.;BMCCancer3,30(2003)
- MechanismofhistonedeacetylaseinhibitorTrichostatinAinducedapoptosisinhumanosteosarcomacells:M.S.Roh,etal.;Apoptosis9,583(2004)
- Cellgrowthinhibitionandgeneexpressioninducedbythehistonedeacetylaseinhibitor,trichostatinA,onhumanhepatomacells:T.Chiba,etal.;Oncology66,481(2004)
- Ahistonedeacetylaseinhibitor,trichostatinA,enhancesradiosensitivitybyabrogatingG2/Marrestinhumancarcinomacells:I.A.Kim,etal.;CancerRes.Treat.37,122(2005)
- Mitoticspindlecheckpointinactivationbytrichostatinadefinesamechanismforincreasingcancercellkillingbymicrotubule-disruptingagents:M.Dowling,etal.;CancerBiol.Ther.4,197(2005)
- TrichostatinA,aninhibitorofhistonedeacetylase,inhibitssmoothmusclecellproliferationviainductionofp21(WAF1):H.Okamoto,etal.;J.Atheroscler.Thromb.13,183(2006)
- InductionofapoptosisandinhibitionoftelomeraseactivitybytrichostatinA,ahistonedeacetylaseinhibitor,inhumanleukemicU937cells:H.J.Woo,etal.;Exp.Mol.Pathol.82,77(2007)
- TrichostatinAdown-regulateDNAmethyltransferase1inJurkatTcells:R.Januchowski,etal.;CancerLett.246,313(2007)
- TrichostatinAcausesp53toswitchoxidative-damagedcolorectalcancercellsfromcellcyclearrestintoapoptosis:C.Habold,etal.;J.CellMol.Med.12,607(2008)
- Anti-inflammatoryeffectofTrichostatin-Aonmurinebonemarrow-derivedmacrophages:S.B.Han&J.K.Lee;Arch.Pharm.Res.32,613(2009)
- TrichostatinAinhibitsosteoclastogenesisandboneresorptionbysuppressingtheinductionofc-FosbyRANKL:H.N.Kim,etal.;Eur.J.Pharmacol.623,22(2009)
- TrichostatinAinhibitsexpressionofcathepsinsinexperimentalosteoarthritis:W.P.Chen,etal.;Rheumatol.Int.31,1325(2011)
- HistoneDeacetylaseInhibitorsinCellPluripotency,Differentiation,andReprogramming:A.Kretsovali,etal.;StemCellsInt.2012,1(2012)
- HDACinhibitorsincreaseNRF2-signalingintumourcellsandblunttheefficacyofco-adminsteredcytotoxicagents:M.McMahon,etal.;PLoSOne9,e114055(2014)
- Kruppel-likefactor4regulatesmatrixmetalloproteinaseandaggrecanasegeneexpressioninchondrocytes:J.Fujikawa,etal.;CellTissueRes.aheadofprint(2017)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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