Adipogen/trans-Indole-3-acrylic acid/AG-CR1-3677-G001/1 g
商品编号：
AG-CR1-3677-G001
品牌：
Adipogen Inc
市场价：
¥1200.00
美元价：
720.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | IAcrA;trans-3-Indoleacrylicacid;trans-β-IndoleacrylicAcid;(E)-3-(1H-Indol-3-yl)acrylicacid;NSC29428;NSC137806;BRN0006317 |
| ProductType | Chemical |
| Properties | |
| Formula | C11H9NO2 |
| MW | 187.2 |
| CAS | 29953-71-7 |
| PurityChemicals | ≥98% |
| Appearance | Off-whitesolid. |
| Solubility | SolubleinDMSOorethanol.Slightlysolubleinwater. |
| OtherProductData | Note:Warmingandsonicationmayberequiredwhendissolvingthecompoundinthesolventofchoice. |
| InChiKey | PLVPPLCLBIEYEA-AATRIKPKSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +20°C |
| LongTermStorage | +4°C |
| HandlingAdvice | Protectfrommoisture. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat+4°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Inflammationsuppressor.Tryptophanmetaboliteproducedbyhumanmicrobiota(intestinalcommensalePeptostreptococcussp.).Involvedinkeepingtheintestinalbarrierintactandworksasanti-inflammatorymolecule.PatientswithInflammatoryBowelDisease(IBD)haveanalteredmicrobiota,withlessPeptostreptococcussp.,andthereforereducedproductionoftrans-indole-3-acrylicacid.
- ChromophoricL-Trpanalogusedtoprobetheallostericpropertiesoftheinternalaldimineoftryptophansynthase.Alsoshowntobeamoderateinhibitoroftryptophansynthase,trypothan-2,3-dioxygenase(TDO),indoleamine-2,3-dioxygenase(IDO),L-dopachromeisomeraseandxanthineoxidase.
- ReagentusedasamatrixforMALDI-TOFmassspectroscopyinordertocharacterizeandanalyzepolyphenolsandsyntheticpolymers.
- Usedasheterocyclicbuildingblockorintermediateforthesynthesisofindolylacrylamide-derivedinhibitors,pharmaceuticalsoragRochemicals.
ProductReferences
- Inhibitionoftryptophansynthetasebyindoleacrylicacid:W.H.Matchett;J.Bacteriol.110,146(1972)
- StereospecificityofhepaticL-tryptophan2,3-dioxygenase:Y.Watanabe,etal.;Biochem.J.189,393(1980)
- Inhibitionofindoleamine2,3-dioxygenaseandtryptophan2,3-dioxygenasebybeta-carbolineandindolederivatives:N.Eguchi;Arch.Biochem.Biophys.232,602(1984)
- ThestructuralbasisfortheinteractionbetweenL-tryptophanandtheEscherichiacolitrpaporepressor:R.Q.Marmorstein,etal.;J.Biol.Chem.262,4922(1987)
- InteractionofIndoleacrylicAcidwithTrpaporepressorfromEscherichiacoli:D.Hu&M.R.Eftink;Arch.Biochem.Biophys.305,588(1993)
- PhotosensiziedinactivationofinfectiousDNAbyurocanicacid,indoleacrylicacidandrhodiukcomplexes:T.Mohammad,etal.;Photochem.Photobiol.59,189(1994)
- DesorptionbehavioranddistributionsoffluorinatedpolymersinMALDIandelectrosprayionizationmassspectrometry:L.Latourte,etal.;Anal.Chem.69,2742(1997)
- Substratespecificityforisomeraseactivityofmacrophagemigrationinhibitoryfactoranditsinhibitionbyindolederivatives:M.Suzuki,etal.;J.Biochem.122,1040(1997)
- Wheredoesindolylacrylicacidcomefrom?:E.Marklova;AminoAcids 17,401(1999)
- NovelallostericeffectorsofthetryptophansynthaseK2L2complexidentifedbycomputer-assistedmolecularmodelling:A.Marabotti,etal.;Biochim.Biophys.Acta1476,287(2000)
- MALDI-TOFmassspectrometryofoligomericfoodpolyphenols:J.D.Reed,etal.;Phytochemistry66,2248(2005)
- Allostericregulationoftryptophansynthasechanneling:theinternalaldimineprobedbytrans-3-indole-3"-acrylatebinding:P.Casino,etal.;Biochemistry46,7728(2007)
- StructuralinsightintotheinhibitionofhumankynurenineaminotransferaseI/glutaminetransaminaseKII:Q.Han,etal.;J.Med.Chem.52,2786(2009)
- Tryptophan2,3-dioxygenase(TDO)inhibitors.3-(2-(pyridyl)ethenyl)indolesaspotentialanticancerimmunomodulators:E.Dolusic,etal.;J.Med.Chem.54,5320(2011)
- Discoveryofindolylacrylamidederivativesashumandiacylglycerolacyltransferase-2selectiveinhibitors:K.Lee,etal.;Org.Biomol.Chem.11,849(2013)
- Synthesis,BIOLOGicalevaluationandmoleculardockingstudiesoftrans-indole-3-acrylamidederivatives,anewclassoftubulinpolymerizationinhibitors:S.N.Baytas,etal.;Bioorg.Med.Chem.22,3096(2014)
- IndoleacrylicacidproducedbycommensalPeptostreptococcus speciessuppressesinflammation:M.Wlodarska,etal.;CellHost&Microbe22,25(2017)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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