Adipogen/Tozasertib/SYN-1092-M010/10 mg
商品编号：
SYN-1092-M010
品牌：
Adipogen Inc
市场价：
¥1620.00
美元价：
972.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | MK-0457;VX-680 |
| ProductType | Chemical |
| Properties | |
| Formula | C23H28N8OS |
| MW | 464.6 |
| CAS | 639089-54-6 |
| PurityChemicals | ≥95% |
| Appearance | Solid. |
| Solubility | SolubleinDMSOorethanol. |
| Declaration | ManufacturedbySynKinase. |
| OtherProductData | Target:AuroraA|KinaseGroup:Other|Substrate:Serine-Threonine ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| InChiKey | GCIKSSRWRFVXBI-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
Inmammals,threeAurorakinases,AuroraA,AuroraB,andAuroraC,areexpressed.AuroraCexpressionismainlyrestrictedtotestis,whereitfunctionsduringmeiosis,whereasAuroraAandBplaykeyfunctionsregulatingmitosis.AuroraAislocalizedtothecentrosomeandspindlepoles,whereitdrivescentrosomematuration,separation,andbipolarspindleassembly.AuroraBisthecentralcomponentofthechromosomalpassengercomplex(CPC)thatalsocontainstheinnercentromereprotein(INCENP),borealin,andsurvivin.Thesenon-enzymaticcomponentsoftheCPCplayakeyroleinregulatingkinaseactivityandlocalization.Over-expressionofAurorakinasescanbeoncogeneicandtheyhavethuslongbeentargetsforcancerthearpy.Tozasertib,orVX-680,isapotentandselectiveinhibitorofAurorakinases,particularlyAuroraAandB.Invitro,VX-680blockscellcycleprogressionandinducesapoptosisinawiderangeofhumantumortypesatlowIC(50)values(i.e.3.38nMforhumanBE-13cells,and14.34nMforNTERAcells).Moreover,VX680,alsohasverypotentKivalues,withinhibitionconstants(Ki)of0.6,18,and46nMforAuroraA,B,andC,respectively.VX-680isalsoeffectiveinvivo,beingusedinaCaki-1xenograftmodel,VX-680demonstrateda75.7%(P<0.001)=""decrease=""in=""caki-1=""xeno-graft=""tumor=""volume=""with=""no=""apparent=""alternation=""in=""animal=""body=""weight,=""peripheral=""blood=""counts,=""or=""other=""biological="">
ProductReferences
- VX-680,apotentandselectivesmall-moleculeinhibitoroftheAurorakinases,suppressestumorgrowthinvivo:E.A.Harrington,etal.;Nat.Med.10,262(2004)
- Novelseriesofpyrrolotriazineanalogsashighlypotentpan-Aurorakinaseinhibitors:S.Abraham,etal.;Bioorg.Med.Chem.Lett.21,5296(2011)
- Developmentofo-chlorophenylsubstitutedpyrimidinesasexceptionallypotentaurorakinaseinhibitors:H.R.Lawrence,etal.;J.Med.Chem.55,7392(2012)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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