Adipogen/Thiocolchicoside/AG-CN2-0076-M025/25 mg
商品编号：
AG-CN2-0076-M025
品牌：
Adipogen Inc
市场价：
¥6400.00
美元价：
3840.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | BRN0072205;NSC147755;Coltramyl;10-thio-Colchicoside;2-Demethoxy-2-glucosidoxythiocolchicine |
| ProductType | Chemical |
| Properties | |
| Formula | C27H33NO10S |
| MW | 563.6 |
| MerckIndex | 14:9324 |
| CAS | 602-41-5 |
| Source/HostChemicals | Semisynthetic. |
| PurityChemicals | ≥95%(NMR) |
| Appearance | Yellowsolid. |
| Solubility | Solubleinwaterorethanol. |
| Identity | Determinedby1H-NMR. |
| InChiKey | LEQAKWQJCITZNK-MSQQGMGVSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlightandmoisture. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Potentcompetitiveγ-aminobutyricacidtypeA(GABAA)receptorantagoNISTandglycinereceptoragonist.
- Weaknicotinicacetylcholinereceptoragonist.
- Musclerelaxant.
- Anti-inflammatory.Hasanalgesicproperties.
- Showsstrongepileptogenicandconvulsantactivity.
- AnticancercompoundthroughinhibitionofNF-κBandNF-κB-regulatedgeneproducts
- Apoptosisinducer.
- SuppressedosteoclastogenesisinducedbyRANKLandtumorcellsviatheNF-κBsignalingpathway.
- Therapeuticoptionforthemanagementofbonemetastaticdisease.
ProductReferences
- AffinityofthiocolchicosideandthiocolchicosideanaloguesforthepostsynapticGABAreceptorsite:K.Biziere,etal.;Eur.J.Pharmacol.75,167(1981)
- Reviewofthetoxicology,pharmacodynamicsandpharmacokineticssofthiocolchicoside,aGABA-agonistmusclerelaxantwithanti-inflammatoryandanalgesicactions:J.M.Janbroers;ActaTher.13,221(1987)
- Interactionofthiocolchicosidewith[3H]strychninebindingsitesinratspinalcordandbrainstem:M.Cimino,etal.;Eur.J.Pharmacol.318,201(1996)
- Focalandsecondarilygeneralisedconvulsivestatusepilepticusinducedbythiocolchicosideintherat:G.Sechi,etal.;Seizure12,508(2003)
- Multicenter,randomized,double-blinded,placebo-controlledtrialofthiocolchicosideinacutelowbackpain:F.Tüzün,etal.;JointBoneSpine70,356(2003)
- ThemusclerelaxantthiocolchicosideisanantagonistofGABAAreceptorfunctioninthecentralnervoussystem:M.Carta,etal.;Neuropharmacology51,805(2006)
- ThiocolchicosideinhibitstheactivityofvarioussubtypesofrecombinantGABA(A)receptorsexpressedinXenopuslaevisoocytes:M.P.Mascia,etal.;Eur.J.Pharmacol.558,37(2007)
- ThiocolchicosideexhibitsanticancereffectsthroughdownregulationofNF-κBpathwayanditsregulatedgeneproductslinkedtoinflammationandcancer:S.Reuter,etal.;CancerPrev.Res.3,1462(2010)
- ThiocolchicosidesuppressesosteoclastogenesisinducedbyRANKLandcancercellsthroughinhibitionofinflammatorypathways:anewuseforanolddrug:S.Reuter,etal.;Br.J.Pharmacol. 165,2127(2012)
- Thiocolchicosideasemi-syntheticderivativeoftheGloryLily:anewweapontofightmetastaticboneresorption?O.Micheau,etal.;Br.J.Pharmacol.165,2124(2012)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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