Adipogen/Thiocolchicine/AG-CN2-0074-M005/5 mg
商品编号：
AG-CN2-0074-M005
品牌：
Adipogen Inc
市场价：
¥700.00
美元价：
420.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 10-Demethoxy-10-methylthiocolchicine;NSC186301 |
| ProductType | Chemical |
| Properties | |
| Formula | C22H25NO5S |
| MW | 415.5 |
| CAS | 2730-71-4 |
| RTECS | GH0878800 |
| Source/HostChemicals | Semisynthetic. |
| PurityChemicals | ≥95%(NMR) |
| Appearance | Yellowsolid. |
| Solubility | Solubleinethanoloracetone.Almostinsolubleinwaterorether. |
| Identity | Determinedby1H-NMR. |
| InChiKey | CMEGANPVAXDBPL-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlightandmoisture. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Antimitoticalkaloid.
- Tubulinpolymerizationandmicrotubuleassemblyinhibitor.
- AxonalCytoskeletonmodulator.
- Inhibitorofautophagosome-lysosomefusion.
- Apoptosisinducer.
- Thiocolchicine-dimerswereshowntobepotenttopoisomeraseIinhibitors.
ProductReferences
- Associationofthiocolchicinewithtubulin:R.M.Chabin&S.B.Hastie;BBRC161,544(1989)
- Effectoftubulinbindingandself-associationonthenear-ultravioletcirculardichroicspectraofcolchicineandanalogues;R.M.Chabin,etal.;Biochemistry29,1869(1990)
- N-acetylcolchinolO-methyletherandthiocolchicine,potentanalogsofcolchicinemodifiedintheCring.EvaluationofthemechaNISTicbasisfortheirenhancedBIOLOGicalproperties:G.J.Kang,etal.;J.Biol.Chem.265,10255(1990)
- Antitumoragents-CLXXV.Anti-tubulinactionof(+)-thiocolchicinepreparedbypartialsynthesis:Q.Shi,etal.;Bioorg.Med.Chem.5,2277(1997)
- AntiproliferativeactivityofcolchicineanaloguesonMDR-positiveandMDR-negativehumancancercelllines:R.DeVincenzo,etal.;AnticancerDrugDes.13,19(1998)
- Biologicalevaluationondifferenthumancancercelllinesofnovelcolchicineanalogs:R.DeVincenzo,etal.;Oncol.Res.11,145(1999)
- Effectsofthiocolchicineonaxonalcytoskeletonoftheratperoneusnerve:P.Ferri,etal.;Exp.Toxicol.Pathol.54,211(2002)
- Thiocolchicinedimers:anovelclassoftopoisomerase-Iinhibitors:G.Raspaglio,etal.;Biochem.Pharmacol.69,113(2005)
- Inhibitorsoftubulinpolymerization:synthesisandbiologicalevaluationofhybridsofvindoline,anhydrovinblastineandvinorelbinewiththiocolchicine,podophyllotoxinandbaccatinIII:D.Passarella,etal.;Bioorg.Med.Chem.16,6269(2008)
- Synthesisandbiologicalevaluationofnovelthiocolchicine-podophyllotoxinconjugates:D.Passarella,etal.;Eur.J.Med.Chem.45,219(2010)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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