Adipogen/Thapsigargin（高纯度）/AG-CN2-0003-M010/10 mg
商品编号：
AG-CN2-0003-M010
品牌：
Adipogen Inc
市场价：
¥9000.00
美元价：
5400.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| ProductType | Chemical |
| Properties | |
| Formula | C34H50O12 |
| MW | 650.8 |
| MerckIndex | 14:9272 |
| CAS | 67526-95-8 |
| Source/HostChemicals | IsolatedfromThapsiagarganica. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Colorlesstowhiteamorphouspowder. |
| Solubility | SolubleinDMSOor100%ethanol. |
| OtherProductData | Preparationof1mMstocksolution:Dissolve0.65mgthapsigarginin1mlsolvent. |
| InChiKey | IXFPJGBNCFXKPI-IVRBKYRWSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlightandmoisture. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- IntracellularCa2+signalingprobe[1].
- SpecificandsensitiveinhibitorofSERCA[2].
- Non-TPA/PMAtumorpromoter[3].
- Histaminereleaseinducer[4].
- Apoptosisinducer[5,6,7,8].
- Mitochondrialdysfunctioninducer[6,8].
- NOSmodulator[9].
- Angiogenesisinhibitor[10].
- Stimulatorofarachidonicacidmetabolisminmacrophages[11].
- Autophagyinducer[12,13].
- TRAILsensitizer[14].
ProductReferences
- Atoolcomingofage:thapsigarginasaninhibitorofsarco-endoplasmicreticulumCa(2+)-ATPases:M.Treiman,etal.;TrendsPharmacol.Sci.19,131(1998)
- InhibitionofthesarcoplasmicreticulumCa2+transportATPasebythapsigarginatsubnanomolarconcentrations:Y.Sagara,&G.Inesi;J.Biol.Chem.266,13503(1991)
- Thapsigargin,ahistaminesecretagogue,isanon-12-O-tetradecanoylphorbol-13-acetate(TPA)typetumorpromoterintwo-stagemouseskincarcinogenesis:H.Hakii,etal.,J.Cancer.Res.Clin.Oncol.111,177(1986)
- OnthemechanismofhistaminereleaseinducedbythapsigarginfromThapsiagarganicaL:S.A.Patkar,etal.;AgentsActions9,53(1979)
- Thapsigargin,aCa(2+)-ATPaseinhibitor,depletestheintracellularCa2+poolandinducesapoptosisinhumanhepatomacells:A.Tsukamoto&Y.Kaneko;CellBiol.Int.17,969(1993)
- ThapsigargininducesmitochondrialdysfunctionandapoptosisinthemastocytomaP815celllineandinmousethymocytes:J.P.Beaver&P.Waring;CellDeathDiffer.3,415(1996)
- Thapsigargininducesacalmodulin/calcineurin-dependentapoptoticcascaderesponsIBLeforthedeathofprostaticcancercells:B.Tombal,etal.;Prostate43,303(2000)
- Thapsigargininducesbiphasicfragmentationofmitochondriathroughcalcium-mediatedmitochondrialfissionandapoptosis:J.R.Hom,etal.;J.CellPhysiol.212,498(2007)
- Thapsigargin,aCa(2+)-ATPaseinhibitor,relaxesrataortavianitricoxideformation:H.Moritoki,etal.;LifeSci.54,PL153(1994)
- Thapsigargininhibitsangiogenesisintheratisolatedaorta:studiesontheroleofintracellularcalciumpools:N.Shukla,etal.;Cardiovasc.Res.49,681(2001)
- Stimulationofarachidonicacidmetabolisminratperitonealmacrophagesbythapsigargin,anon-(12-O-tetradecanoylphorbol-13-acetate)(TPA)-typetumorpromoter:K.Ohuchi,etal.;CancerRes.Clin.Oncol.113,319(1987)
- Regulationofautophagybytheinositoltrisphosphatereceptor:A.Criollo,etal.;CellDeathDiffer.14,1029(2007)
- AMPK-independentinductionofautophagybycytosolicCa2+increase:A.Grotemeier,etal.;Cell.Signal.22,914(2010)
- NovelHTSstrategyidentifiesTRAIL-sensitizingcompoundsactingspecificallythroughtheCaspase-8apoptoticaxis:D.Finlay,etal.;PLoSOne5,e13375(2010)
- DevelopmentofanEnhancedPhenotypicScreenofCytotoxicT-LymphocyteLyticGranuleExocytosisSuitableforUsewithSyntheticCompoundandNaturalProductCollections:Z.Zhao,etal.;J.Biomol.Screen21,556(2016)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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