Adipogen/TG003/AG-CR1-3656-M005/5 mg
商品编号：
AG-CR1-3656-M005
品牌：
Adipogen Inc
市场价：
¥1600.00
美元价：
960.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | (Z)-1-(3-Ethyl-5-methoxy-2,3-dihydrobenzothiazol-2-ylidene)propan-2-one |
| ProductType | Chemical |
| Properties | |
| Formula | C13H15NO2S |
| MW | 249.3 |
| CAS | 300801-52-9 |
| PurityChemicals | ≥98% |
| Appearance | Solid. |
| Solubility | SolubleinDMSO(20mg/ml),ethanol(15mg/ml)orDMF(15mg/ml). |
| Identity | Determinedby1H-NMR. |
| InChiKey | BGVLELSCIHASRV-QPEQYQDCSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Keepunderinertgas. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Potent,specific,reversIBLeandATP-competitivecellpermeableinhibitorofCdc2-likekinase(Clk)(IC50=15nM,20nM,200nMand>10µMformClk4,mClk1,mClk2andmClk3,respectively).Cdc2-likekinase(Clk),amonganumberofotherkinases,phosphorylatesserine/arginine-richproteinswhichplayaroleinalternativesplicingofpre-mRNA.
- DYRK1AandDYRK1Binhibitor.
- Splicingmodulatorcompound.RegulatesalternativesplicingandreducesthephosphorylationofSF2/ASF1.
- Suppressesserine/arginine-richproteinphosphorylationandaffectstheregulationofalternativesplicingbyphosphorylationofSRproteinbothinvitroandinvivo.
- PotentialdrugforDuchennemusculardystrophy.
- ThereductionofClk2expressioninthehypothalamusbychronicpharmacologicalinhibitionabolishedtheanorexigeniceffectofinsulinandleptin,toincreasebodyweight,fatmass,foodintakeandtodecreaseenergyexpenditureinmice.
ProductReferences
- ManipulationofalternativesplicingbyanewlydevelopedinhibitorofClks:M.Muraki,etal.;J.Biol.Chem.279,24246(2004)
- Alternativesplicing:anewdrugtargetofthepost-genomeera:M.Hagiwara;Biochim.Biophys.Acta1754,324(2005)(Review)
- Chemicaltreatmentenhancesskippingofamutatedexoninthedystrophingene:A.Nishida,etal.;Nat.Commun.2,308(2001)
- Evaluationofsubstituted6-arylquinazolin-4-aminesaspotentandselectiveinhibitorsofcdc2-likekinases(Clk):B.T.Mott,etal.;Bioorg.Med.Chem.Lett.19,6700(2009)
- DevelopmentofanovelselectiveinhibitoroftheDownsyndrome-relatedkinaseDyrk1A:Y.Ogawa,etal.;Nat.Commun.1,86(2010)
- Stress-responsivematurationofClk1/4pre-mRNAspromotesphosphorylationofSRsplicingfactor:K.Ninomiya,etal.;J.CellBiol.195,27(2011)
- Designandsynthesisofthiazolo[5,4-f]quinazolinesasDYRK1Ainhibitors,partII:A.Foucourt,etal.;Molecules19,15411(2014)
- Decipheringtargetingrulesofsplicingmodulatorcompounds:caseofTG003:M.Sakuma,etal.;BMCMol.Biol.16,16(2015)
- Cdc2-likekinase2inthehypothalamusisnecessarytomaintainenergyhomeostasis:P.G.Quaresma,etal.;Int.J.Obes.41,268(2017)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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