Adipogen/Telithromycin/BVT-0456-M001/1 mg
商品编号：
BVT-0456-M001
品牌：
Adipogen Inc
市场价：
¥1600.00
美元价：
960.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | RU66647;Ketek;HMR3647 |
| ProductType | Chemical |
| Properties | |
| Formula | C43H65N5O10 |
| MW | 812.0 |
| CAS | 191114-48-4 |
| RTECS | HB7878000 |
| Source/HostChemicals | Semi-synthetic. |
| PurityChemicals | ≥98%(NMR,TLC) |
| Appearance | Whitesolid. |
| Solubility | SolubleinDMSO,ethanol,methanol,acetoneormethylenechloride.Sparinglysolubleinwater(0.3mg/ml). |
| Identity | Determinedby1H-NMR. |
| Declaration | ManufacturedbyBioViotica. |
| InChiKey | LJVAJPDWBABPEJ-XLSPMWLOSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | +4°C |
| HandlingAdvice | Protectfromlightwheninsolution. |
| Use/StABIlity | Stableforatleast1yearafterreceiptwhenstoredat+4°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Ketolidetypemacrolideantibiotic.
- Antibacterialcompoundusedtotreatmildtomoderaterespiratoryinfections.
- Proteinsynthesisinhibitor,bybindingtothe50Sribosomalsubunitandsubsequentlyblockingtheprogressionofthegrowingpolypeptidechain.BindstodomainsIIandVofthe23SrRNAofthe50Sribosomalsubunit.
- HasahigheraffinityfortheseribosomaltargetsthanconventionalmacrolidesduetotheadditionalinteractionsandincreasedbindingatdomainII.RetainsactivityagainstGram-positivecocciinthepresenceofresistancemediatedbymethylases(ermgenes)thatalterthebindingsiteatdomainV.
- Mayinhibittheformationofribosomalsubunits50Sand30S.
ProductReferences
- TheketolideantibioticsHMR-3647andHMR3004areactiveagainstToxoplasmagondiiinvitroandinmurinemodelsofinfection:F.G.Araujo,etal.;Antimicrob.AgentsChemother.41,2137(1997)
- Thein-vitroactivityofHMR3647,anewketolideantimicrobialagent:F.J.Boswell,etal.;J.Antimicrob.Chemother.42,703(1998)
- Drugsofthe21stcentury:telithromycin(HMR3647)-thefirstketolide:G.Ackermann&A.C.Rodloff;J.Antimicrob.Chemother.51,497(2003)
- Telithromycin:K.Wellington&S.Noble;Drugs64,1683(2004)
- Telithromycin:Aketolideantibioticfortreatmentofrespiratorytractinfections:J.R.Lonks&D.A.Goldmann;Clin.Inf.Dis.40,1657(2005)
- Antibacterialdrugdiscovery-Then,nowandthegenomicsfuture:R.Monaghan&J.F.Barrett;Biochem.Pharmacol.71,901(2006)
- Telithromycininthetreatmentofpneumococcalcommunity-acquiredrespiratorytractinfections:areview:C.M.Fogarty,etal.;Int.J.Infect.Dis.10,136(2006)
- Benefit-riskassessmentoftelithromycininthetreatmentofcommunity-acquiredpneumonia:S.D.Brown;DrugSafety31,561(2008)
- Time-dependenteffectsofKlebsiellapneumoniaendotoxinonthetelithromycinpharmacokineticsinrats;restorationoftheparametersin96-hourKPLPSratstothecontrollevels:J.H.Lee,etal.;Pulm.Pharmacol.Ther.21,860(2008)
- Ketolides-themodernrelativesofmacrolides:thepharmacokineticperspective:M.Zeitlinger,etal.;Clin.Pharmacokinet.48,23(2009)
- InducIBLeexpressionoferm(B)bytheketolidestelithromycinandcethromycin:P.Byoungduck&M.Yu-Hong;Int.J.Antimicrob.Agents46,226(2015)
- ClpP-independentfunctionofClpXinterfereswithtelithromycinresistanceconferredbymsr(A)inStaphylococcusaureus:V.Vimberg,etal.;Antimicrob.AgentsChemother.59,3611(2015)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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