Adipogen/TBB/AG-CR1-3660-M025/25 mg
商品编号：
AG-CR1-3660-M025
品牌：
Adipogen Inc
市场价：
¥1800.00
美元价：
1080.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 4,5,6,7-Tetrabromo-2-azabenzimidazole;Tetrabromobenzotriazole;NSC231634;TBBt |
| ProductType | Chemical |
| Properties | |
| Formula | C6HBr4N3 |
| MW | 434.7 |
| CAS | 17374-26-4 |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Solid. |
| Solubility | SolubleinDMSO(20mg/ml). |
| InChiKey | OMZYUVOATZSGJY-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- ATP/GTP-competitivecellpermeablecaseinkinaseII(CK2)inhibitor(IC50=0.9µMforratliver.LesspotentlyinhibitsCCK2/cyclinA,GSK3βandphosphorylasekinase(IC50=15.6,11.2and8.7µM,respectively).BindstotheVal66residueofCK2andinhibitsthebindingofATP/GTP.
- ModerateDYRK1Ainhibitor(IC50=4.4µM).
- Inducescaspase-dependentapoptosisanddegradeshematopoieticlineagecell-specificprotein1(HS1)inJurkatcells.
ProductReferences
- Selectivityof4,5,6,7-tetrabromobenzotriazole,anATPsite-directedinhibitorofproteinkinaseCK2("caseinkinase-2"):S.Sarno,etal.;FEBSLett.496,44(2001)
- ProteinkinaseCK2inhibitor4,5,6,7-tetrabromobenzotriazole(TBB)inducesapoptosisandcaspase-dependentdegradationofhaematopoieticlineagecell-specificprotein1(HS1)inJurkatcells:M.Ruzzene,etal.;Biochem.J.364,41(2002)
- Alternativebindingmodesofaninhibitortotwodifferentkinases:E.DeMoliner,etal.,Eur.J.Biochem.270,3174(2003)
- OptimizationofproteinkinaseCK2inhibitorsderivedfrom4,5,6,7-tetrabromobenzimidazole:M.A.Pagano,etal.;J.Med.Chem.47,6239(2004)
- Tetrabromobenzotriazole(TBBt)andtetrabromobenzimidazole(TBBz)asselectiveinhibitorsofproteinkinaseCK2:evaluationoftheireffectsoncellsanddifferentmolecularformsofhumanCK2:P.Zien,etal.;Biochim.Biophys.Acta1754,271(2005)
- TheselectivityofinhibitorsofproteinkinaseCK2:Anupdate:M.A.Pagano,etal.;Biochem.J.415,353(2008)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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