Adipogen/TBB/AG-CR1-3660-M005/5 mg
商品编号：
AG-CR1-3660-M005
品牌：
Adipogen Inc
市场价：
¥600.00
美元价：
360.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | 4,5,6,7-Tetrabromo-2-azabenzimidazole; Tetrabromobenzotriazole; NSC 231634; TBBt |
| Product Type | Chemical |
| Properties | |
| Formula | C6HBr4N3 |
| MW | 434.7 |
| CAS | 17374-26-4 |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | Solid. |
| Solubility | Soluble in DMSO (20mg/ml). |
| InChi Key | OMZYUVOATZSGJY-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- ATP/GTP-competitive cell permeable casein kinase II (CK2) inhibitor (IC50=0.9µM for rat liver. Less potently inhibits CCK2/cyclin A, GSK3β and phosphorylase kinase (IC50=15.6, 11.2 and 8.7µM, respectively). Binds to the Val66 residue of CK2 and inhibits the binding of ATP/GTP.
- Moderate DYRK1A inhibitor (IC50=4.4µM).
- Induces caspase-dependent apoptosis and degrades hematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells.
Product References
- Selectivity of 4,5,6,7-tetrabromobenzotriazole, an ATP site-directed inhibitor of protein kinase CK2 ('casein kinase-2'): S. Sarno, et al.; FEBS Lett. 496, 44 (2001)
- Protein kinase CK2 inhibitor 4,5,6,7-tetrabromobenzotriazole (TBB) induces apoptosis and caspase-dependent degradation of haematopoietic lineage cell-specific protein 1 (HS1) in Jurkat cells: M. Ruzzene, et al.; Biochem. J. 364, 41 (2002)
- Alternative binding modes of an inhibitor to two different kinases: E. De Moliner, et al., Eur. J. Biochem. 270, 3174 (2003)
- Optimization of protein kinase CK2 inhibitors derived from 4,5,6,7-tetrabromobenzimidazole: M.A. Pagano, et al.; J. Med. Chem. 47, 6239 (2004)
- Tetrabromobenzotriazole (TBBt) and tetrabromobenzimidazole (TBBz) as selective inhibitors of protein kinase CK2: evaluation of their effects on cells and different molecular forms of human CK2: P. Zien, et al.; Biochim. Biophys. Acta 1754, 271 (2005)
- The selectivity of inhibitors of protein kinase CK2: An update: M.A. Pagano, et al.; Biochem. J. 415, 353 (2008)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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