Adipogen/Tamoxifen citrate salt/CDX-T0201-G005/5 g
商品编号：
CDX-T0201-G005
品牌：
Adipogen Inc
市场价：
¥5180.00
美元价：
3108.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | (Z)-1-(p-Dimethylaminoethoxyphenyl)-1,2-diphenyl-1-butene;ICI46474;Istubal;Kessar;Noltam;Nolvadex;TMX;Valodex;Zemide |
| ProductType | Chemical |
| Properties | |
| Formula | C26H29NO.C6H8O7 |
| MW | 563.64 |
| CAS | 54965-24-1 |
| PurityChemicals | ≥98% |
| Appearance | Whitepowder. |
| Solubility | SolubleinDMSOormethanol.Slightlysolubleinethanol. |
| Identity | DeterminedbyNMR. |
| Declaration | ManufacturedbyChemodex. |
| OtherProductData | ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| InChiKey | FQZYTYWMLGAPFJ-OQKDUQJOSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +20°C |
| LongTermStorage | +4°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlightandmoisture. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat+4°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
Selectiveestrogenreceptormodulator(SERM)usedasadjuvanttherapyforestrogen-dependentbreastcancer.AntagoNISTofERactioninbreasttissueandbreastcancercellsandERagonistinbone,uterus,andthecardiovasculaturesystem.ThisprodrugismetabolizedbycytochromeP450(CYP450)enzymestotheactivemetabolitesN-desmethyl-TMX,4-hydroxy-N-desmethyl-TMX(endoxifen)and4-hydroxy-TMX(afimoxifene).N,N-Didesmethyl-4-hydroxytamoxifen(norendoxifen),anotheractivemetabolitehasbeenfoundtoactasapotentcompetitivearomataseinhibitorandmayalsobeinvolvedinitsantiestrogenicactivity.Bindsmicrosomalantiestrogenbindingsites,alteringcholesterolesterificationattherapeuticdosesandimpactingbreastcancercelldifferentiation,apoptosis,andautophagy.ProteinkinaseC(PKC)inhibitorandanti-angiogeneticfactor.
ProductReferences
(1)K.B.Horwitz&W.L.McGuire;J.Biol.Chem.253,8185(1978)|(2)V.C.Jordan,etal.;CancerTreat.Rep.64,745(1980)|(3)C.A.O"Brian,etal.;CancerRes.45,2462(1985)|(4)K.J.Edwards,etal.;J.Med.Chem.35,2753(1992)|(5)M.Clarke,etal.;Lancet351,1451(1998)|(6)D.A.Tonetti&V.C.Jordan;Mol.Med.Today2,218(1996)|(7)J.M.Hall,etal.;J.Biol.Chem.276,36869(2001)|(8)P.Thomas,etal.;Endocrinol.146,624(2005)|(9)M.S.Singh,etal.;Breast20,111(2011)|(10)P.deMedina,etal.;Chem.Phys.Lip.164,432(2011)|(11)V.K.Todorova,etal.;CancerChemother.Pharmacol.67,285(2011)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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