Adipogen/T-2 Toxin/AG-CN2-0473-M005/5 mg
商品编号：
AG-CN2-0473-M005
品牌：
Adipogen Inc
市场价：
¥3800.00
美元价：
2280.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Epoxytrichothecene;FusariotoxinT-2;Insariotoxin;MycotoxinT-2;NSC138780 |
| ProductType | Chemical |
| Properties | |
| Formula | C24H34O9 |
| MW | 466.5 |
| CAS | 21259-20-1 |
| RTECS | YD0100000 |
| Source/HostChemicals | IsolatedfromfungusFusariumtricinctum. |
| PurityChemicals | ≥98%(TLC) |
| Appearance | Whitesolid. |
| Solubility | SolubleinDMSO(30mg/ml),ethanol(20mg/ml)ordichloromethane. |
| InChiKey | BXFOFFBJRFZBQZ-CNLOIQPPSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Commontrichothecenemycotoxin,whichcaninfectgraincropscausingalimentarytoxicaleukiainhumansandanimals.
- InhibitsDNAandRNAsynthesisinvivoandinvitroandcaninduceapoptosis.InvivothecompoundrapidlymetabolizestoHT-2mycotoxin(amajormetabolite).
- Inhibitsproteinsynthesisthroughitshighbindingaffinitytopeptidyltransferase,whichisanintegralpartofthe60Sribosomalsubunit,resultinginactivationofJNK/p38MAPKs.
- Interfereswiththemetabolismofmembranephospholipidsandincreasesliverlipidperoxides.
- Increasesblood-brainbarrierpermeabilityandinhibitsmonoamineoxidaseactivityinbrain.
- Reactiveoxygenspecies(ROS)inducer.
ProductReferences
- ThestructuresoftoxinsfromtwostrainsofFusariumtricinctum:J.R.Bamburg,etal.;Tetrahedron24,3329(1968)
- MeasurementofthestabilityofT-2toxininaqueoussolution:J.Mary,etal.;Chem.Res.Tox.6,524(1993)
- T-2toxin-inducedapoptosisinlymphoidorgansofmice:J.Shinozuka,etal.;Exp.Toxicol.Pathol.49,387(1997)
- ApoptoticcellulardamageinmiceafterT-2toxin-inducedacutetoxicosis:T.Ihara,etal.;Nat.Toxins5,141(1997)
- T-2toxin-inducedapoptosisinhematopoietictissuesofmice:J.Shinozuka,etal.;Toxicol.Pathol.26,674(1998)
- EffectofT-2toxinonblood-brainbarrierpermeabilitymonoamineoxidaseactivityandproteinsynthesisinrats:J.Wang,etal.;FoodChem.Toxicol.36,955(1998)
- CytotoxicityandrelatedeffectsofT-2toxinonculturedVerocells:C.Bouaziz,etal.;Toxicon48,343(2006)
- Mechanismsofmycotoxin-inducedneurotoxicitythroughoxidativestress-associatedpathways:K.Doi&K.Uetsuka;Int.J.Mol.Sci.12,5213(2011)
- T-2toxin,atrichothecenemycotoxin:reviewoftoxicity,metabolism,andanalyticalmethods:Y.Li,etal.;J.Agric.FoodChem.59,3441(2011)
- ThefungalT-2toxinalterstheactivationofprimarymacrophagesinducedbyTLR-agoNISTsresultinginadecreaseoftheinflammatoryresponseinthepig:J.Seeboth,etal.;Vet.Res.43,1(2012)
- Oxidativestress-mediatedcytotoxicityandmetabolismofT-2toxinanddeoxynivalenolinanimalsandhumans:anupdate:Q.H.Wu,etal.;Arch.Toxicol.88,1309(2014)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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