Adipogen/T-2 Toxin/AG-CN2-0473-M001/1 mg
商品编号：
AG-CN2-0473-M001
品牌：
Adipogen Inc
市场价：
¥960.00
美元价：
576.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | Epoxytrichothecene; Fusariotoxin T-2; Insariotoxin; Mycotoxin T-2; NSC 138780 |
| Product Type | Chemical |
| Properties | |
| Formula | C24H34O9 |
| MW | 466.5 |
| CAS | 21259-20-1 |
| RTECS | YD0100000 |
| Source/Host Chemicals | Isolated from fungus Fusarium tricinctum. |
| Purity Chemicals | ≥98% (TLC) |
| Appearance | White solid. |
| Solubility | Soluble in DMSO (30mg/ml), ethanol (20mg/ml) or dichloromethane. |
| InChi Key | BXFOFFBJRFZBQZ-CNLOIQPPSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice |
Keep cool and dry. Protect from light. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- Common trichothecene mycotoxin, which can infect grain crops causing alimentary toxic aleukia in humans and animals.
- Inhibits DNA and RNA synthesis in vivo and in vitro and can induce apoptosis. In vivo the compound rapidly metabolizes to HT-2 mycotoxin (a major metabolite).
- Inhibits protein synthesis through its high binding affinity to peptidyl transferase, which is an integral part of the 60S ribosomal subunit, resulting in activation of JNK/p38 MAPKs.
- Interferes with the metabolism of membrane phospholipids and increases liver lipid peroxides.
- Increases blood-brain barrier permeability and inhibits monoamine oxidase activity in brain.
- Reactive oxygen species (ROS) inducer.
Product References
- The structures of toxins from two strains of Fusarium tricinctum: J.R. Bamburg, et al.; Tetrahedron 24, 3329 (1968)
- Measurement of the stability of T-2 toxin in aqueous solution: J. Mary, et al.; Chem. Res. Tox. 6, 524 (1993)
- T-2 toxin-induced apoptosis in lymphoid organs of mice: J. Shinozuka, et al.; Exp. Toxicol. Pathol. 49, 387 (1997)
- Apoptotic cellular damage in mice after T-2 toxin-induced acute toxicosis: T. Ihara, et al.; Nat. Toxins 5, 141 (1997)
- T-2 toxin-induced apoptosis in hematopoietic tissues of mice: J. Shinozuka, et al.; Toxicol. Pathol. 26, 674 (1998)
- Effect of T-2 toxin on blood-brain barrier permeability monoamine oxidase activity and protein synthesis in rats: J. Wang, et al.; Food Chem. Toxicol. 36, 955 (1998)
- Cytotoxicity and related effects of T-2 toxin on cultured Vero cells: C. Bouaziz, et al.; Toxicon 48, 343 (2006)
- Mechanisms of mycotoxin-induced neurotoxicity through oxidative stress-associated pathways: K. Doi & K. Uetsuka; Int. J. Mol. Sci. 12, 5213 (2011)
- T-2 toxin, a trichothecene mycotoxin: review of toxicity, metabolism, and analytical methods: Y. Li, et al.; J. Agric. Food Chem. 59, 3441 (2011)
- The fungal T-2 toxin alters the activation of primary macrophages induced by TLR-agonists resulting in a decrease of the inflammatory response in the pig: J. Seeboth, et al.; Vet. Res. 43, 1 (2012)
- Oxidative stress-mediated cytotoxicity and metabolism of T-2 toxin and deoxynivalenol in animals and humans: an update: Q.H. Wu, et al.; Arch. Toxicol. 88, 1309 (2014)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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