Adipogen/Swinholide A/AG-CN2-0035-C010/10 µg
商品编号：
AG-CN2-0035-C010
品牌：
Adipogen Inc
市场价：
¥1900.00
美元价：
1140.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| ProductType | Chemical |
| Properties | |
| Formula | C78H132O20 |
| MW | 1389.9 |
| CAS | 95927-67-6 |
| Source/HostChemicals | IsolatedfrommarinespongeTheonellaswinhoei. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Colorlessoil. |
| Solubility | Solubleinethanol,methanol,DMSO,acetoneorethylacetate. |
| InChiKey | RJVBVECTCMRNFG-VGHOFLFQSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Cellpermeabledimericdilactonemacrolide[1].
- Cytotoxiccompound[1,2,7].
- Specificactinfilament(F-actin)inhibitor.DisruptstheactinCytoskeletonbysequesteringactindimersandrapidlyseveringactinfilaments(F-actin)[3,5,7,8].
- Depolymerizesactinfilaments(F-actin)[6].
- Antifungal[4].
- Apoptosisinducer[9].
- AlteratestheactincytoskeletonofGH4cellsandinhibitsinsulin-increasedprolactingenetranscription[10].
ProductReferences
- Marinenaturalproducts.XXIII.Threenewcytotoxicdimericmacrolides,swinholidesBandCandisoswinholideA,congenersofswinholideA,fromtheOkinawanmarinespongeTheonellaswinhoei:M.Kobayashi,etal.;Chem.Pharm.Bull.(Tokyo)38,2960(1990)
- Marinenaturalproducts.XXXI.Structure-activitycorrelationofapotentcytotoxicdimericmacrolideswinholideA,fromtheOkinawanmarinespongeTheonellaswinhoei,anditsisomers:M.Kobayashi,etal.;Chem.Pharm.Bull.(Tokyo)42,19(1994)
- SwinholideAisaMICROFILamentdisruptingmarinetoxinthatstabilizesactindimersandseversactinfilaments:M.R.Bubb,etal.;J.Biol.Chem.270,3463(1995)
- TwoclassesofmetabolitesfromTheonellaswinhoeiarelocalizedindistinctpopulationsofbacterialsymbionts:C.A.Bewley,etal.;Experientia52,716(1996)
- UseoftheF-actin-bindingdrugs,misakinolideAandswinholideA:M.R.Bubb&I.Spector;MethodsEnzymol.298,26(1998)
- Actin-depolymerizingeffectofdimericmacrolides,bistheonellideAandswinholideA:S.Y.Saito,etal.;J.Biochem.123,571(1998)
- Actin-bindingmarinemacrolides:totalsynthesisandBIOLOGicalimportance:K.S.Yeung&I.Paterson;Angew.Chem.Int.Ed.Engl.41,4632(2002)(Review)
- StructuralbasisofswinholideAbindingtoactin:V.A.Klenchin,etal.;Chem.Biol.12,287(2005)
- Actincytoskeletonderangementinducesapoptosisinrenalischemia/reperfusion:M.Genescà,etal.;Apoptosis11,563(2006)
- Insulin-increasedprolactingeneexpressionrequiresactintreadmilling:potentialroleforp21activatedkinase:F.M.Stanley;Endocrinol.148,5874(2007)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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