Adipogen/Suramin . hexasodium salt/AG-CR1-3575-M250/250 mg
商品编号：
AG-CR1-3575-M250
品牌：
Adipogen Inc
市场价：
¥3200.00
美元价：
1920.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Germanin;NSC34936;SK24728 |
| ProductType | Chemical |
| Properties | |
| Formula | C51H34N6O23S6.6Na |
| MW | 1291.2.137.9 |
| MerckIndex | 14:9006 |
| CAS | 129-46-4 |
| RTECS | QM7000000 |
| Source/HostChemicals | Synthetic. |
| PurityChemicals | ≥98%(PharmaceuticalGrade). |
| Appearance | Whitetooff-whitepowder. |
| Solubility | SolubleinwaterorDMSO.Sparinglysolubleinethanol. |
| OtherProductData | WaterContent(byKarlFischer):≤15% |
| InChiKey | VAPNKLKDKUDFHK-UHFFFAOYSA-H |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | +4°C |
| HandlingAdvice | Keepcoolanddry. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat+4°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- PotentATPaseinhibitor[1].
- Potentcompetitiveinhibitorofreversetranscriptase.Showsanti-HIVactivity[2,3].
- Anticancercompound[4,5,15].
- ProteinkinaseC(PKC)inhibitor[4].
- Potentinhibitorofmelanomaheparanaseandtumorcellmetastasis[6].
- Non-specificgrowthfactorsinhibitor(includingPDGF,EGF,aFGFandbFGF)[7,16].
- TGF-β1inhibitor[8].
- TopoisomeraseIandIIinhibitor[9].
- Interleukin-1(IL-1)inhibitor[10].
- Interleukin-4(IL-4)inhibitor[11].
- Gproteininhibitor[12].
- P2XandP2YpurinergicreceptorantagoNIST[13].
- Antiangiogenic.PotentVEGFinhibitor[14,15].
- Telomeraseinhibitor[17].
- Showsadjuvantproperties[18].
- Regulatesryanodinereceptor[19].
- Directadenylylcyclaseinhibitor[20].
- Proteinsynthesisinhibitor[21].
- SIRT1(sirtuin1)andSIRT5(sirtuin5)inhibitor[22,23].
- Immunosuppressive[24].
- Antifibroticagent[25].
- Antiparasitic.Antiprotozoal.Athelmintic[26].
- Cullin-RINGE3ubiquitinligaseinhibitor[27].
ProductReferences
- Suramin:apotentATPaseinhibitorwhichactsontheinsidesurfaceofthesodiumpump:P.A.Fortes,etal.;Biochim.Biophys.Acta318,262(1973)
- Suramin:apotentinhibitorofthereversetranscriptaseofRNAtumorviruses:E.DeClerq;CancerLett.8,9(1979)
- SuraminprotectionofTcellsinvitroagainstinfectivityandcytopathiceffectofHTLV-III:H.Mitsuya,etal.;Science226,172(1984)
- Suramin,ananti-cancerdrug,inhibitsproteinkinaseCandinducesdifferentiationinneuroblastomacellcloneNB2A:C.E.Hensey,etal.;FEBSLett.258,156(1989)
- Suramin:prototypeofanewgenerationofantitumorcompounds:R.V.LaRocca,etal.;CancerCells2,106(1990)(Review)
- Suramin.Apotentinhibitorofmelanomaheparanaseandinvasion:M.Nakajima,etal.;J.Biol.Chem.266,9661(1991)
- Natureoftheinteractionofgrowthfactorswithsuramin:C.R.Middaugh,etal.;Biochemistry31,9016(1992)
- TheantiproliferativeeffectofsuraminonthecancercelllineSW-13ismediatedbytheinhibitionoftransforminggrowthfactorbeta1(TGF-beta1):R.Danesi,etal.;Pharmacol.Res.25,17(1992)
- SuramininhibitsDNAdamageinhumanprostatecancercellstreatedwithtopoisomeraseinhibitorsinvitro:H.Yamazaki,etal.;Prostate23,25(1993)
- Suraminblocksthebindingofinterleukin-1toitsreceptorandneutralizesIL-1BIOLOGicalactivities:G.Strassmann,etal.;Int.J.Immunopharmacol.16,931(1994)
- Suraminblocksbindingofinterleukin-4toitsreceptorsonhumantumorcellsandinterleukin-4-inducedmitogenicresponse:P.Leland,etal.;Oncol.Res.7,227(1995)
- Suraminanaloguesassubtype-selectiveGproteininhibitors:M.Freissmuth,etal.; Mol.Pharmacol.49,602(1996)
- PPADSandsuraminasantagonistsatclonedP2Y-andP2U-purinoceptors:S.J.Charlton,etal.;Br.J.Pharmacol.118,704(1996)
- Suraminisapotentinhibitorofvascularendothelialgrowthfactor.Acontributiontothemolecularbasisofitsantiangiogenicaction:J.Waltenberger,etal.;J.Mol.CellCardiol.28,1523(1996)
- Antiangiogenicandantiproliferativeactivityofsuraminanalogues:A.R.Gagliardi,etal.;CancerChemother.Pharmacol.41,117(1998)
- Suppressionofmyocardialinflammationusingsuramin,agrowthfactorblocker:T.Shiono,etal.; Circ.J.66,385(2002)
- Suraminsuppressesgrowth,alkaline-phosphataseandtelomeraseactivityofhumanosteosarcomacellsinvitro:K.Trieb&H.Blahovec;Int.J.Biochem.CellBiol.35,1066(2003)
- Suraminhasadjuvantpropertiesandpromotesexpansionofantigen-specificTh1andTh2cellsinvivo:M.Denkinger,etal.;Int.Immunopharmacol.4,15(2004)
- Functionalregulationofthecardiacryanodinereceptorbysuraminandcalmodulininvolvesmultiplebindingsites:A.P.Hill,etal;Mol.Pharmacol.65,1258(2004)
- Modulationofadenylylcyclaseactivityinyoungandadultratbraincortex.Identificationofsuraminasadirectinhibitorofadenylylcyclase:J.Stöhr,etal.;J.CellMol.Med.9,940(2005)
- Inhibitionbysuraminofproteinsynthesisinvitro.Ribosomesasthetargetofthedrug:M.Brigotti,etal.; Biochimie88,497(2006)
- Structure-activitystudiesonsuraminanaloguesasinhibitorsofNAD+-dependenthistonedeacetylases(sirtuins):J.Trapp,etal.;ChemMedChem2,1419(2007)
- StructuralbasisofinhibitionofthehumanNAD+-dependentdeacetylaseSIRT5bysuramin:A.Schuetz,etal.;Structure15,377(2007)
- SuramininhibitstheCD40-CD154costimulatoryinteraction:apossIBLemechanismforimmunosuppressiveeffects:E.Margolles-Clark,etal.;Biochem.Pharmacol.77,1236(2009)
- Tissueprotectiveandanti-fibroticactionsofsuramin:newusesofanolddrug:N.Liu&S.Zhuang;Curr.Clin.Pharmacol.6,137(2011)(Review)
- Thetrypanocidaldrugsuraminandothertrypanbluemimeticsareinhibitorsofpyruvatekinasesandbindtotheadenosinesite:H.P.Morgan,etal.;J.Biol.Chem.286,31232(2011)
- Suramininhibitscullin-RINGE3ubiquitinligases:K.Wu,etal.;PNAS113,E2011(2016)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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