Adipogen/Streptozotocin/AG-CN2-0046-M050/50 mg
商品编号：
AG-CN2-0046-M050
品牌：
Adipogen Inc
市场价：
¥500.00
美元价：
300.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose;Streptozocin;STZ;NSC85998;AntibioticU9889;Zanosar |
| ProductType | Chemical |
| Properties | |
| Formula | C8H15N3O7 |
| MW | 265.2 |
| MerckIndex | 14:8832 |
| CAS | 18883-66-4 |
| RTECS | LZ5775000 |
| PurityChemicals | ≥98%(HPLC) ≥75%(αanomer) |
| Appearance | Off-whitetopaleyellowpowder. |
| Solubility | Solubleinwaterorethanol. |
| Identity | DeterminedbyUVandIR. |
| OtherProductData | Note:OncethecompoundisinsolutionitspontaneouslyreleasesNOgasatroomtemperature.Werecommendtopreparefreshsolutionsimmediatelybeforeuse. LIT:Anomer-equilibratedstreptozotocinsolutionfortheinductionofexperimentaldiabetesinmice(Musmusculus):A.S.delaGarza-Rodea,etal.;J.Am.Assoc.Lab.Anim.Sci.49,40(2010) |
| InChiKey | ZSJLQEPLLKMAKR-GKHCUFPYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Antibiotic[1].
- Diabetogenic.Diabetesinducer.Inducesdiabetesmellitusinanimalmodelsthroughitstoxiceffectsonpancreaticβ-cells[2,5,13,14].
- Mutagenic[3,10].
- Potentalkylatingagent.PotentDNAmethylatingagent[4,10].
- Nitricoxide(NO)donor.Vasorelaxant[6].
- CytotoxictocellsthatexpressGLUT2glucosetransporter[7].
- O-GlcNAc-selectiveN-acetyl-β-D-glucosaminidase(O-GlcNAcase)inhibitor[8].
- Genotoxic.InducesDNAdamage.ProducesDNAstrandbreaks[9,10].Celldeathinducer[15].
- Antineoplastic.Anti-canceragentusedinchemotherapy[10,11].
- InducescellcylcearrestatG2[12].
ProductReferences
- Streptozotocin,anewantibacterialantibiotic:J.J.Vavra,etal.;Antibiot.Ann.7,230(1959)
- StudiesonthediabetogenicactionofStreptozotocin:N.Raketien,etal.;CancerChemother.Rep.29,91(1963)
- MutagenicactivityofStreptozotocin:S.M.Kolbye&M.S.Legator;Mutat.Res.6,387(1968)
- AlkylationofDNAinrattissuesfollowingadmiNISTrationofstreptozotocin:R.A.Bennett&A.E.Pegg;CancerRes.41,2786(1981)
- Streptozotocininteractionswithpancreaticbetacellsandtheinductionofinsulin-dependentdiabetes:G.L.Wilson&E.H.Leiter;Curr.Top.Microbiol.Immunol.156,27(1990)(Review)
- Nitricoxidegenerationfromstreptozotocin:N.S.Kwon,etal.;FASEBJ.8,529(1994)
- STZtransportandcytotoxicity.SpecificenhancementinGLUT2-expressingcells:W.J.Schnedl,etal.;Diabetes43,1326(1994)
- GlucosestimulatesproteinmodificationbyO-linkedGlcNAcinpancreaticbetacells:linkageofO-linkedGlcNActobetacelldeath:K.Liu,etal.;PNAS97,2820(2000)
- ChromosomalresponseofhumanlymphocytestoStreptozotocin:A.D.Bolzan&M.S.Bianchi;Mutat.Res.503,63(2002)
- Genotoxicityofstreptozotocin:A.D.Bolzan&M.S.Bianchi;Mutat.Res.512,121(2002)(Review)
- Clastogeniceffectsofstreptozotocinonhumancoloncancercelllineswithgeneamplification:A.D.Bolzan&M.S.Bianchi; J.Environ.Pathol.Toxicol.Oncol.22,281(2003)
- StreptozotocininducesG2arrestinskeletalmusclemyoblastsandimpairsmusclegrowthinvivo:A.P.Johnston,etal.;Am.J.Physiol.CellPhysiol.292,C1033(2007)
- Themechanismsofalloxan-andstreptozotocin-induceddiabetes:S.Lenzen;Diabetologia51,216(2008)
- Mechanismsoftoxiceffectofstreptozotocinonβ-cellsintheisletsoflangerhans:V.B.Pisarev,etal.;Bull.Exp.Biol.Med.148,937(2009)
- Theroleofprogrammedcelldeathinstreptozotocin-inducedearlydiabeticnephropathy:W.H.Wu,etal.;J.Endocrinol.Invest.34,e296(2011)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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