Adipogen/Staurosporine/AG-CN2-0022-M001/1 mg
商品编号：
AG-CN2-0022-M001
品牌：
Adipogen Inc
市场价：
¥2400.00
美元价：
1440.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | AntibioticAM2282;Antibiotic230;CCRIS3272 |
| ProductType | Chemical |
| Properties | |
| Formula | C28H26N4O3 |
| MW | 466.5 |
| MerckIndex | 14:8802 |
| CAS | 62996-74-1 |
| RTECS | KC655000 |
| Source/HostChemicals | IsolatedfromStreptomycesspiralis. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Off-whitetoyellowsolid. |
| Solubility | SolubleinDMSO,ethylacetateordimethylformamide.Insolubleinwater. |
| InChiKey | HKSZLNNOFSGOKW-FYTWVXJKSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfrommoisture. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Antibiotic.
- Antifungalandanti-yeastactivity[1].
- InhibitsplateletaggregationinducedbycollagenorADP.Hasnoeffectonthrombin-inducedplateletaggregation[2].
- Potent,cellpermeable,reversIBLe,ATP-competitiveandbroadspectruminhibitorofproteinkinases.InhibitsproteinkinaseA,CaMkinase,myosinlightchainkinase,proteinkinaseC,proteinkinaseG,CDK1/cyclinB,CDK2/cyclinA,CDK4/cyclinD,CDK5/p25,GSK-3βandPim-1kinase[3,4,5,6,12].
- DYRK1Ainhibitor(IC50=20nM)[13].
- Keyapoptosisinducer[7,8,10,11].
- TopoisomeraseII(TopoII)inhibitor[9].
ProductReferences
- AnewalkaloidAM-2282ofStreptomycesorigin.Taxonomy,fermentation,isolationandpreliminarycharacterization:S.Omura,etal.;J.Antibiot.(Tokyo)30,275(1977)
- Staurosporine,apotentplateletaggregationinhibitorfromaStreptomycesspecies:S.Oka,etal.;Agric.Biol.Chem.50,2723(1986)
- Staurosporine,apotentinhibitorofphospholipid/Ca++dependentproteinkinase:T.Tamaoki,etal.;BBRC135,397(1986)
- Staurosporineinhibitstyrosine-specificproteinkinaseactivityofRoussarcomavirustransformingproteinp60:N.Nakano,etal.;J.Antibiot.(Tokyo)40,706(1987)
- Staurosporine,K-252andUCN-01:potentbutnonspecificinhibitorsofproteinkinases:U.T.Ruegg&G.M.Burgess;TIPS10,218(1989)(Review)
- Staurosporine:aneffectiveinhibitorforCa2+/calmodulin-dependentproteinkinaseII:N.Yanagihara,etal.;J.NeuRochem.56,294(1991)
- Inductionofacommonpathwayofapoptosisbystaurosporine:R.Bertrand,etal.;Exp.CellRes.211,314(1994)
- Staurosporineinducesprogrammedcelldeathinembryonicneuronsandactivationoftheceramidepathway:D.A.Wiesner&G.Dawson;J.Neurochem.66,1418(1996)
- MechanismoftopoisomeraseIIinhibitionbystaurosporineandotherproteinkinaseinhibitors:P.Lassotaetal.;J.Biol.Chem.271,26418(1996)
- Characterizationofthecelldeathprocessinducedbystaurosporineinhumanneuroblastomacelllines:J.Boix,etal.;Neuropharmacology36,811(1997)
- Molecularmechanismofstaurosporine-inducedapoptosisinosteoblasts:H.J.Chae,etal.;Pharmacol.Res.42,373(2000)
- Pim-1ligand-boundstructuresrevealthemechanismofserine/threoninekinaseinhibitionbyLY294002:M.D.Jacobs,etal.;J.Biol.Chem.280,13728(2005)
- Generationofpotentandselectivekinaseinhibitorsbycombinatorialbiosynthesisofglycosylatedindolocarbazoles:C.Sanchez,etal.;Chem.Commun.2009,4118(2009)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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