Adipogen/Splitomicin/AG-CR1-0088-M005/5 mg
商品编号：
AG-CR1-0088-M005
品牌：
Adipogen Inc
市场价：
¥900.00
美元价：
540.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | Splitomycin;1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one;1-Naphthalenpropanoicacid |
| ProductType | Chemical |
| Properties | |
| Formula | C13H10O2 |
| MW | 198.2 |
| CAS | 5690-03-9 |
| PurityChemicals | ≥98%(NMR) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | Solubleinmethanol,ethanolorDMSO. |
| Identity | Determinedby1H-NMR. |
| OtherProductData | HandlingNote:Afterreconstitutionuseimmediatelyduetodecomposition.Werecommendtousefreshsolutions.Ifyoupreparealiquotsstoreimmediatelyat-20°C. |
| InChiKey | ISFPDBUKMJDAJH-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Afterreconstitution,preparealiquotsandstoreat-20°C. Keepcoolanddry. Keepunderinertgas. Protectfromlightandmoisture. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- PotentcellpermeableandselectiveinhibitorofyeastNAD+-dependenthistonedeacetylase(HDAC)Sir2p[1-4].
- Displayshigheractivityinvivothaninvitro[1-4].
- SensitizesmammaliancellstoavarietyofDNA-damagingagentsbyabrogatingSir2pactivityonp53.Actsbyeitheralteringorblockingaccesstotheacetylatedhistonebindingpocket[5].
- Showntohavediverseeffectsalsoinmammaliancells[6-10].
ProductReferences
- IdentificationofasmallmoleculeinhibitorofSir2p:A.Bedalov,etal.;PNAS98,15113(2001)
- IdentificationofselectiveinhibitorsofNAD+-dependentdeacetylasesusingphenotypicscreensinyeast:M.Hirao,etal.;J.Biol.Chem.278,52773(2003)
- InhibitorsofSir2:evaluationofsplitomicinanalogues:J.Posakony,etal.;J.Med.Chem.47,2635(2004)
- TheSir2familyofproteindeacetylases:J.M.Denu;Curr.Opin.Chem.Biol.9,431(2005)(Review)
- Histonedeacetylaseinhibitor-mediatedrADIosensitizationofhumancancercells:classdifferencesandthepotentialinfluenceofp53:I.A.Kim,etal.;Clin.CancerRes.12,940(2006)
- SIRT1inhibitionalleviatesgenesilencinginFragileXmentalretardationsyndrome:R.Biacsi,etal.;PLoSGenet.4,e1000017(2008)
- SplitomicinsuppresseshumanplateletaggregationviainhibitionofcyclicAMPphosphodiesteraseandintracellularCa++release:F.C.Liu,etal.;Thromb.Res.124,199(2009)
- ReciprocalrolesofSIRT1andSKIPintheregulationofRARactivity:implicationintheretinoicacid-inducedneuronaldifferentiationofP19cells:M.R.Kang,etal.;NucleicAcidsRes.38,822(2010)
- Sirt1inhibitionpromotesinvivoarterialthrombosisandtissuefactorexpressioninstimulatedcells:A.Breitenstein,etal.;Cardiovasc.Res.89,464(2011)
- Sirtuin-1targetingpromotesFoxp3+T-regulatorycellfunctionandprolongsallograftsurvival:U.H.Beier,etal.;Mol.CellBiol.31,1022(2011)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
联络我们
