Adipogen/SMI-4a/AG-CR1-3503-M005/5 mg
商品编号：
AG-CR1-3503-M005
品牌：
Adipogen Inc
市场价：
¥1800.00
美元价：
1080.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | (5E/Z)-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione |
| ProductType | Chemical |
| Properties | |
| Formula | C11H6F3NO2S |
| MW | 273.2 |
| CAS | 327033-36-3 |
| PurityChemicals | ≥95%(NMR) |
| Appearance | Whitetooff-whitesolid. |
| Solubility | SolubleinDMSO(atleast5mg/ml). |
| Identity | Determinedby1H-NMR. |
| InChiKey | NGJLOFCOEOHFKQ-YVMONPNESA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- SelectiveinhibitorofPim-1andPim-2proteinkinases[1-5].
- InducerofG1phasecellcyclearrest[1-5].
- Inducerofp27Kip1[1-5].
- Inducerofapoptosisthroughthemitochondrialpathway[1-5].
- InhibitorofthemammaliantargetofrapamycinC1(mTORC1)pathway[1-5].
- Downregulatesc-myc[1-5].
- InhibitorofPRAS40phosphorylationandmTORactivity[1-5].
- Potentialanti-cancercompound[2,4,5].
- Blocksprostatecancergrowth[2,4,5].
ProductReferences
- SynthesisandevaluationofnovelinhibitorsofPim-1andPim-2proteinkinases:Z.Xia,etal.;J.Med.Chem.52,74(2009)
- Novelbenzylidene-thiazolidine-2,4-dionesinhibitPimproteinkinaseactivityandinducecellcyclearrestinleukemiaandprostatecancercells:Z.Beharry,etal.;Mol.CancerTher.8,1473(2009)
- PIM1proteinkinaseregulatesPRAS40phosphorylationandmTORactivityinFDCP1cells:F.Zhang,etal.;CancerBiol.Ther.8,846(2009)
- AsmallmoleculeinhibitorofPimproteinkinasesblocksthegrowthofprecursorT-celllymphoblasticleukemia/lymphoma:Y.-W.Lin,etal.;Blood115,824(2010)
- RegulationofSkp2levelsbythePim-1proteinkinase:B.Cen,etal.;JBC285,29128(2010)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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