Adipogen/Sipholenol A/AG-CN2-0506-C100/100 µg
商品编号：
AG-CN2-0506-C100
品牌：
Adipogen Inc
市场价：
¥2700.00
美元价：
1620.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | NSC378977 |
| Product Type | Chemical |
| Properties | |
| Formula | C30H52O4 |
| MW | 476.7 |
| CAS | 78518-73-7 |
| Source/Host Chemicals | Isolated from marine sponge Siphonochalina siphonella. |
| Purity Chemicals | ≥98% (HPLC) |
| Appearance | White to off-white lyophilized powder. |
| Solubility | Soluble in DMSO or 100% ethanol (25mg/ml). |
| InChi Key | LVWWPNAIMBYRKG-KOHQYJKCSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Keep cool and dry. |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- Efficient inhibitor of P-glycoprotein (Pgp, MDR-1) function through direct interactions. By inhibiting MDR-1, active compounds remain in the cytoplasm longer and allowing them to be more effective within the cell.
- Reversing agent for the treatment of multidrug resistance (MDR) in Pgp-overexpressing tumors. Potentiates the cytotoxicity of established Pgp substrates such as colchicine, vinblastine and paclitaxel.
- Antiproliferative and cytotoxic compound.
- Potent antifouling compound.
Product References
- New triterpenoids from the Red Sea sponge Siphonochalina siphonella: Y. Kashman, et al.; J. Nat. Prod. 64, 175 (2001)
- Biocatalysis of the anticancer sipholane triterpenoids: S. Jain, et al.; Planta Med. 73, 591 (2007)
- Sipholenol A, a marine-derived sipholane triterpene, potently reverses P-glycoprotein (ABCB1)-mediated multidrug resistance in cancer cells: Z. Shi, et al.; Cancer Sci. 98, 1373 (2007)
- Sipholane triterpenoids: chemistry, reversal of ABCB1/P-glycoprotein-mediated multidrug resistance, and pharmacophore modeling: S. Jain, et al.; J. Nat. Prod. 72, 1291 (2009)
- Esters of the marine-derived triterpene sipholenol A reverse P-GP-mediated drug resistance: Y. Zhang, et al.; Mar. Drugs 13, 2267 (2015)
- Potent antifouling metabolites from Red Sea organisms: S.S. Al-Lihaibi, et al.; Asian J. Chem. 27, 2252 (2015)
- Antiproliferative effects of triterpenoidal derivatives, obtained from the marine sponge Siphonochalina sp. on human hepatic and colorectal cancer cells: A. Abdel-Lateff, et al.; Z. Naturforsch. C. 71, 29 (2016)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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