Adipogen/Simocyclinone D8/BVT-0290-M005/5 mg
商品编号：
BVT-0290-M005
品牌：
Adipogen Inc
市场价：
¥5400.00
美元价：
3240.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Product Type | Chemical |
| Properties | |
| Formula | C46H42ClNO18 |
| MW | 932.3 |
| CAS | 301845-97-6 |
| Source/Host Chemicals | Isolated from Streptomyces antibioticus Tü 6040. |
| Purity Chemicals | ≥97% (HPLC) |
| Appearance | Yellow powder. |
| Solubility | Soluble in DMSO, methanol, acetone, dichloromethane or ethyl acetate. |
| Identity | Determined by 1H-NMR. |
| Declaration | Manufactured by BioViotica. |
| InChi Key | PLEGMCYXNQPJNV-TYXWGSLYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Handling Advice | Protect from light when in solution. |
| Use/Stability |
Stable for at least 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- Antibiotic.
- Bacterial DNA gyrase inhibitor: Staphylococcus aureus (IC50= 1.45µM), E. coli (IC50= 0.41µM).
- Human topoisomerase II (Topo II) inhibitor (IC50= 100µM).
- Antibacterial (Gram-positive).
- Antitumor compound.
Product References
- Simocyclinones, novel cytostaticangucyclinone antibiotics produced by StreptomycesantibioticusTu 6040. I. Taxonomy, fermentation, isolation and biological activities: J. Schimana, et al.; J. Antibiot. 53, 779 (2000)
- Biosynthesis of simocyclinone D8 in an 18O2-rich atmosphere: M. Holzenkämpfer & A. Zeeck; J. Antibiot. 55, 341 (2002)
- Simocyclinones, novel cytostaticangucyclinone antibiotics produced by StreptomycesantibioticusTu 6040 II. Structure elucidation and biosynthesis: M. Holzenkämpfer, et al.; J. Antibiot. 55, 301 (2002)
- Simocyclinone D8, an inhibitor of DNA gyrase with a novel mode of action: R.H. Flatman, et al.; Antimicrob. Agents Chemother. 49, 1093 (2005)
- A crystal structure of the bifunctional antibiotic simocyclinone D8, bound to DNA gyrase: M.J. Edwards, et al.; Science 326, 1415 (2009)
- In vivo and in vitro patterns of the activity of simocyclinone D8, an angucyclinone antibiotic from Streptomycesantibioticus: L.M. Oppegard, et al.; Antimicrob. Agents Chemother. 53, 2110 (2009)
- Mapping simocyclinone D8 interaction with DNA gyrase: evidence for a new binding site on GyrB: C. Sissi, et al.;Antimicrob. Agents Chemother. 54, 213 (2009)
- The aminocoumarins: biosynthesis and biology: L. Heide; Nat. Prod. Rep. 26, 1241 (2009) (Review)
- Anti-proliferative effects of simocyclinone D8 (SD8), a novel catalytic inhibitor of topoisomerase II: A.A. Sadiq, et al.; Invest New Drugs 28, 20 (2010)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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