Adipogen/Sildenafil citrate/SYN-3016-M005/5 mg
商品编号：
SYN-3016-M005
品牌：
Adipogen Inc
市场价：
¥2380.00
美元价：
1428.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | Viagra; Revatio |
| Product Type | Chemical |
| Properties | |
| Formula | C22H30N6O4S . C6H8O7 |
| MW | 474.6 . 192.1 |
| CAS | 171599-83-0 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO or ethanol. |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: PDE5 | Kinase Group: N/A | Substrate: N/A Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | DEIYFTQMQPDXOT-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS | No |
| Product Specification Sheet | |
| Datasheet |
 Download PDF |
Sildenafil citrate is an orally active selective inhibitor of cGMP-specific PDE5 (phosphodiesterase type 5), an enzyme that regulates blood flow in the penis and which is the predominant PDE isoenzyme in human corpora cavernosa. Sildenafil citrate is used as an agent to treat erectile dysfunction and pulmonary arterial hypertension (PAH). Studies in vitro have shown that sildenafil has between 10 and 10,000-fold greater selectivity for PDE5 than for other phosphodiesterase isoforms (PDEs 1, 2, 3, 4, 6, 7 to 11). In particular, sildenafil has greater than 4,000-fold selectivity for PDE5 over PDE3, the cAMP-specific phosphodiesterase isoform involved in the control of cardiac contractility. Sildenafil is a weak inhibitor of the cytochrome P450 isoforms 1A2, 2C9, 2C19, 2D6, 2E1 and 3A4 (IC50 >150 mM).
Product References
- Effects of sildenafil on the relaxation of human corpus cavernosum tissue in vitro and on the activities of cyclic nucleotide phosphodiesterase isozymes: S.A. Ballard, et al.; J. Urol. 159, 2164 (1998)
- Inhibition of cyclic GMP-binding cyclic GMP-specific phosphodiesterase (Type 5) by sildenafil and related compounds: I.V. Turko, et al.; Mol. Pharmacol. 56, 124 (1999)
- Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond: H.A. Ghofrani, et al.; Nat. Rev. Drug Discov. 5, 689 (2006)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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