Adipogen/Sildenafil citrate/CDX-S0078-M250/250 mg
商品编号：
CDX-S0078-M250
品牌：
Adipogen Inc
市场价：
¥9420.00
美元价：
5652.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | 5-[2-Ethoxy-5-(4-methylpiperazin-1-yl)sulfonylphenyl]-1-methyl-3-propyl-4H-pyrazolo[5,4-e]pyrimidin-7-onecitratesalt;Actra-Rx;Edegra;Viagra;Tonafil;Apodefil;UK92480 |
| ProductType | Chemical |
| Properties | |
| Formula | C22H30N6O4S.C6H8O7 |
| MW | 474.6.192.1 |
| CAS | 171599-83-0 |
| Source/HostChemicals | Synthetic. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Whitetooff-whitepowder. |
| Solubility | SolubleinDMSO(20mg/ml). |
| Identity | DeterminedbyNMR. |
| Declaration | ManufacturedbyChemodex. |
| OtherProductData | ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| InChiKey | DEIYFTQMQPDXOT-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +20°C |
| LongTermStorage | +4°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlightandmoisture. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat+4°C. |
| Documents | |
| MSDS | No |
| ProductSpecificationSheet | |
| Datasheet |  DownloadPDF |
PotentcGMP-specificphosphodiesteraseinhibitorthatishighlyselectiveforPDE5.ItinhibitsPDE5activityinisolatedrabbitplateletswithanIC50valueof3.6nM(3nMinhumancorpuscavernosum)comparedtoinhibitionofPDE1andPDE3activities(IC50s=0.26and65μM,respectively).InhibitionofPDE5enhancestherelaxationofsmoothmuscleinarangeofvasculartissuesbyprolongingthenitricoxide/cGMP-mediatedactivationofcGMP-dependentproteinkinase.Whilemostnotableforitsuseinthetreatmentoferectiledysfunction,sildenafil’svasorelaxantpropertieshavealsobeenusedtocontrolvasculartoneinpulmonaryarterialhypertensionandhigh-altitudepulmonaryedemaassociatedwithaltitudesickness.Thecitratesalthassuperiorwatersolubilityandpharmacokineticscomparedtothebasesaltofsildenafil.
ProductReferences
(1)N.K.Terrett,etal.;Bioorg.Med.Chem.Lett.6,1819(1996)|(2)J.Richalet,etal.;Am.J.Respir.Crit.CareMed.171,275(2005)|(3)C.E.Teixeira,etal.;J.Pharmacol.Exp.Ther.316,654(2006)|(4)S.Jung,etal.;Arch.Pharm.Res.34,451(2011)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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