Adipogen/Shikonin/AG-CN2-0487-M010/10 mg
商品编号：
AG-CN2-0487-M010
品牌：
Adipogen Inc
市场价：
¥960.00
美元价：
576.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | (+)-Shikonin;(R)-Shikonin;TokyoViolet;NSC252844;IsoarNEBin4;C.I.75535;(R)-5,8-Dihydroxy-2-(1-hydroxy-4-methylpent-3-en-1-yl)naphthalene-1,4-dione |
| ProductType | Chemical |
| Properties | |
| Formula | C16H16O5 |
| MW | 288.3 |
| CAS | 517-89-5 |
| Source/HostChemicals | IsolatedfromAlkannasp. |
| PurityChemicals | ≥98%(HPLC) |
| Appearance | Purpleredsolid. |
| Solubility | SolubleinDMSOorDMF.Sparinglysolubleinethanol,methanolorwater. |
| Identity | Determinedby1H-NMR. |
| InChiKey | NEZONWMXZKDMKF-SNVBAGLBSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| HandlingAdvice | Keepcoolanddry. Protectfromlight. |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
- Anticancercompound.InhibitsTNF-α-inducedandB-16melanoma-inducedangiogenesis.
- InducesapoptosisandRIP1-andRIP3-dependentnecroptosisinseveralcancercells.Circumventscancerantidrugresistancethroughthenecroptosispathway.
- Proteasomeinhibitor.Autophagyinducer.
- TopoisomeraseIinhibitor.
- Inhibitsglycolysisincancercellsbyinhibitingtumor-specificpyruvatekinaseM2(PKM2).
- Anti-inflammatorycompound.Inhibitsleukocytemigration,downregulateschemokinereceptorexpression,andinhibitsHIV-1replication.
- InhibitstheactivationofNLRP3andAIM2inflammasome.Showntodirectlytargetcaspase-1andasainhibitorofPKM2toblockPKM2-mediatedglycolysisthatpromotesinflammasomeactivationbymodulatingEIF2AK2phosphorylationinmacrophages.
- Antioxidant.FreerADIcalscavenger.
- Directlyinhibitsnitricoxidesynthase(NOS).
- Regulatorofsystemicglucosetolerance,energybalanceandadiposity/obesity.Adipogenesisinhibitor.Showntoinhibitfataccumulationinadipocytes.
- Antibacterialandantifungalagent.
ProductReferences
- Antitumoractivityofshikoninanditsderivatives:U. Sankawa,etal.;Chem.Pharm.Bull.(Tokyo)25,2392(1977)
- Acomparativestudyonanti-inflammatoryactivitiesoftheenantiomers,shikoninandalkannin:S.Tanaka,etal.;J.Nat.Prod.49,466(1986)
- Shikonin,aningredientofLithospermumerythrorhizon,inhibitsangiogenesisinvivoandinvitro:T.Hisa,etal.;AnticancerRes.18,783(1998)
- Shikonin,acomponentofantiinflammatoryChineseherbalmedicine,selectivelyblockschemokinebindingtoCCchemokinereceptor-1:X.Chen,etal.;Int.Immunopharmacol.1,229(2001)
- Shikonin,acomponentofchineseherbalmedicine,inhibitschemokinereceptorfunctionandsuppresseshumanimmunodeficiencyvirustype1:X.Chen,etal.;Antimicrob.AgentsChemother.47,2810(2003)
- InductionofapoptosisbyshikoninthroughaROS/JNK-mediatedprocessinBcr/Abl-positivechronicmyelogenousleukemia(CML)cells:X.Mao,etal.;CellRes.18,879(2008)
- DualroleofshikonininearlyandlatestagesofcollagentypeIIarthritis:Q.Dai,etal.;Mol.Biol.Rep.36,1597(2009)
- Shikoninexertsantitumoractivityviaproteasomeinhibitionandcelldeathinductioninvitroandinvivo:H.Yang,etal.;Int.J.Cancer124,2450(2009)
- Shikonininhibitsfataccumulationin3T3-L1adipocytes:H.Lee,etal.;Phytother.Res.24,344(2010)
- Shikonindirectlyinhibitsnitricoxidesynthases:possIBLetargetsthataffectthoracicaortarelaxationresponseandnitricoxidereleasefromRAW264.7macrophages:L.S.Yoshida,etal.;J.Pharmacol.Sci.112,343(2010)
- ShikonininhibitsadipogenesisbymodulationoftheWNT/β-cateninpathway:H.Lee,etal.;LifeSci.88,294(2011)
- Shikoninanditsanalogsinhibitcancercellglycolysisbytargetingtumorpyruvatekinase-M2:J.Chen,etal.;Oncogene30,4297(2011)
- Shikonindirectlytargetsmitochondriaandcausesmitochondrialdysfunctionincancercells:B.Wiench,etal.;Evid.BasedComplementAlternat.Med.2012,726025(2012)
- InhibitoryeffectofShikoninonCandidaalbicansgrowth:H.Miao,etal.;Biol.Pharm.Bull.35,1956(2012)
- TopoisomeraseIinhibitors,shikoninandtopotecan,inhibitgrowthandinduceapoptosisofgliomacellsandgliomastemcells:F.L.Zhang,etal.;PLoSOne8,e81815(2013)
- Theanti-tumoreffectofshikoninonosteosarcomabyinducingRIP1andRIP3dependentnecroptosis:Z.Fu,etal.;BMCCancer13,580(2013)
- Evaluationofradicalscavengingpropertiesofshikonin:L.S.Yoshida,etal.;J.Clin.Biochem.Nutr.55,90(2014)
- ShikoninpromotesautophagyinBXPC-3humanpancreaticcancercellsthroughthePI3K/Aktsignalingpathway:S.Shi&H.Cao;Oncol.Lett.8,1087(2014)
- TheMechanismUnderlyingtheAntibacterialActivityofShikoninagainstMethicillin-ResistantStaphylococcusaureus:Y.S.Lee,etal.;Evid.BasedComplementAlternat.Med.2015,520578(2015)
- Decreasedadiposityandenhancedglucosetoleranceinshikonintreatedmice:A.Bettaieb,etal.;Obesity23,2269(2015)
- ShikoninSuppressesNLRP3andAIM2InflammasomesbyDirectInhibitionofCaspase-1:J.Zorman,etal.;PLoSOne11,e0159826(2016)
- PKM2-dependentglycolysispromotesNLRP3andAIM2inflammasomeactivation:M.Xie,etal.;Nat.Commun.7,13280(2016)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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