Adipogen/Selumetinib/SYN-1016-M100/100 mg
商品编号：
SYN-1016-M100
品牌：
Adipogen Inc
市场价：
¥21380.00
美元价：
12828.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | AZD6244; ARRY-142886 |
| Product Type | Chemical |
| Properties | |
| Formula | C17H15BrClFN4O3 |
| MW | 457.7 |
| CAS | 606143-52-6 |
| Purity Chemicals | ≥95% |
| Appearance | Solid. |
| Solubility | Soluble in DMSO. Slightly soluble (<1mg l)="" in="" ethanol.=""> |
| Declaration | Manufactured by SynKinase. |
| Other Product Data |
Target: mTOR | Kinase Group: Atypical (PIKK) | Substrate: Serine-Threonine Click here for Original Manufacturer Product Datasheet Our product description may differ slightly from the original manufacturers product datasheet. |
| InChi Key | CYOHGALHFOKKQC-UHFFFAOYSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
Selumetinib (AZD6244) is a second-generation, orally available, potent and selective ATP non-competitive inhibitor of MEK 1/2. In direct assays, AZD6244 selectively inhibits purified active MEK1 and MEK2 with an IC(50) of 14nM, and AZD6244 has reported IC(50) values of <100nm for="" mek1="" in="" elisa="" assays="" and="" in="" bindings="" assays="" against="" recombinant="" domains="" of="" mek2,="" kd="" values="" were="" 53nm="" for="" azd6244.="" azd6244="" demonstrated="" very="" effective="" anti-proliferation="" effects="" against="" several="" different="" cell="" lines="" with="" ic(50)="" values="" ranging="" from="" a="" low="" of="" 3nm="" to="">< 1µm="" depending="" upon="" the="" cell="" system="" used,="" and="" the="" compound="" inhibits="" basal="" and="" growth="" factor-stimulated="" phosphorylation="" of="" erk1/="" 2="" with="" ic(50)="" concentrations="">< 40nm.="" azd6244="" has="" demonstrated="" potent="" dose-dependent="" antitumor="" activity="" against="" a="" panel="" of="" mouse="" xenograft="" models="" of="" colorectal,="" pancreatic,="" liver,="" skin,="" and="" lung="" cancer,="" and="" inhibition="" of="" tumor="" growth="" was="" found="" to="" correlate="" with="" the="" reduction="" of="" phospho-erk1/2="" levels="" in="">
Product References
- Biological characterization of ARRY-142886 (AZD6244), a potent, highly selective mitogen-activated protein kinase kinase 1/2 inhibitor: T.C. Yeh, et al.; Clin. Cancer. Res. 13, 1576 (2007)
- Optimization of allosteric MEK inhibitors. Part 1: Venturing into underexplored SAR territories: I.V. Hartung, et al.; Bioorg. Med. Chem. Lett. 23, 2384 (2013)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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