Adipogen/Selumetinib/SYN-1016-M010/10 mg
商品编号：
SYN-1016-M010
品牌：
Adipogen Inc
市场价：
¥4320.00
美元价：
2592.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductDetails | |
|---|---|
| Synonyms | AZD6244;ARRY-142886 |
| ProductType | Chemical |
| Properties | |
| Formula | C17H15BrClFN4O3 |
| MW | 457.7 |
| CAS | 606143-52-6 |
| PurityChemicals | ≥95% |
| Appearance | Solid. |
| Solubility | SolubleinDMSO.Slightlysoluble(<1mg l)="" in="" ethanol.=""> |
| Declaration | ManufacturedbySynKinase. |
| OtherProductData | Target:mTOR|KinaseGroup:Atypical(PIKK)|Substrate:Serine-Threonine ClickhereforOriginalManufacturerProductDatasheet Ourproductdescriptionmaydifferslightlyfromtheoriginalmanufacturersproductdatasheet. |
| InChiKey | CYOHGALHFOKKQC-UHFFFAOYSA-N |
| ShippingandHandling | |
| Shipping | AMBIENT |
| ShortTermStorage | +4°C |
| LongTermStorage | -20°C |
| Use/StABIlity | Stableforatleast2yearsafterreceiptwhenstoredat-20°C. |
| Documents | |
| MSDS |  DownloadPDF |
| ProductSpecificationSheet | |
| Datasheet | DownloadPDF |
Selumetinib(AZD6244)isasecond-generation,orallyavailable,potentandselectiveATPnon-competitiveinhibitorofMEK1/2.Indirectassays,AZD6244selectivelyinhibitspurifiedactiveMEK1andMEK2withanIC(50)of14nM,andAZD6244hasreportedIC(50)valuesof<100nm for="" mek1="" in="" elisa="" assays="" and="" in="" bindings="" assays="" against="" recombinant="" domains="" of="" mek2,="" kd="" values="" were="" 53nm="" for="" azd6244.="" azd6244="" demonstrated="" very="" effective="" anti-proliferation="" effects="" against="" several="" different="" cell="" lines="" with="" ic(50)="" values="" ranging="" from="" a="" low="" of="" 3nm="" to=""><1µm=""depending=""upon=""the=""cell=""system=""used,=""and=""the=""compound=""inhibits=""basal=""and=""growth=""factor-stimulated=""phosphorylation=""of=""erk1/=""2=""with=""ic(50)=""concentrations=""><40nm.=""azd6244=""has=""demonstrated=""potent=""dose-dependent=""antitumor=""activity=""against=""a=""panel=""of=""mouse=""xenograft=""models=""of=""colorectal,=""pancreatic,=""liver,=""skin,=""and=""lung=""cancer,=""and=""inhibition=""of=""tumor=""growth=""was=""found=""to=""correlate=""with=""the=""reduction=""of=""phospho-erk1/2=""levels=""in="">
ProductReferences
- BIOLOGicalcharacterizationofARRY-142886(AZD6244),apotent,highlyselectivemitogen-activatedproteinkinasekinase1/2inhibitor:T.C.Yeh,etal.;Clin.Cancer.Res.13,1576(2007)
- OptimizationofallostericMEKinhibitors.Part1:VenturingintounderexploredSARterritories:I.V.Hartung,etal.;Bioorg.Med.Chem.Lett.23,2384(2013)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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