Adipogen/Sclerotiorin/AG-CN2-0054-MC05/0.5 mg
商品编号：
AG-CN2-0054-MC05
品牌：
Adipogen Inc
市场价：
¥2200.00
美元价：
1320.00
产品分类：
其他试剂
公司分类：
Other_reagents
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| Product Details | |
|---|---|
| Synonyms | (S-(R*,R*-(E,E)))-Sclerotiorin |
| Product Type | Chemical |
| Properties | |
| Formula | C21H23ClO5 |
| MW | 390.9 |
| CAS | 549-23-5 |
| Source/Host Chemicals | Isolated from fungus Penicillium sp. |
| Purity Chemicals | ≥97% (HPLC) |
| Appearance | Yellow solid. |
| Solubility | Soluble in DMSO, ethanol or DMF. Sparingly soluble in aqueous buffers. |
| Identity | Determined by 1H-NMR. |
| Other Product Data | Solubility in aqueous buffers: Dissolve in DMF and then dilute with the aqueous buffer of choice. Sclerotiorin has a solubility of approx. 0.3mg/ml in a 1:2 solution of DMF:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day. |
| InChi Key | SWJLTKXURNHVHE-UPWXJBBJSA-N |
| Shipping and Handling | |
| Shipping | AMBIENT |
| Short Term Storage | +4°C |
| Long Term Storage | -20°C |
| Use/Stability | Stable for at least 2 years after receipt when stored at -20°C. |
| Documents | |
| MSDS |
 Download PDF |
| Product Specification Sheet | |
| Datasheet |
Download PDF |
- Antibiotic [4, 6, 7].
- Antibacterial [4, 6, 7] with anticancer activity [8].
- Weak antagonist of human endothelin receptor A (ETA) and B (ETB) [1].
- Cholesteryl ester transfer protein (CETP) activity inhibitor [2].
- Grb2-Shc binding inhibitor [3].
- Potent aldose reductase inhibitor [4].
- Potent reversible, non-competitive soybean lipoxygenase-1 (LOX-1) inhibitor [5].
- Antioxidant. Free radical scavenger [5].
- Antifungal [6, 7].
Product References
- Azaphilones with endothelin receptor binding activity produced by Penicillium sclerotiorum: taxonomy, fermentation, isolation, structure elucidation and biological activity: L. Pairet, et al.; J. Antibiot. (Tokyo) 48, 913 (1995)
- Structure-specific inhibition of cholesteryl ester transfer protein by azaphilones: H. Tomoda, et al.; J. Antibiot. (Tokyo) 52, 160 (1999)
- Sclerotiorin and isochromophilone IV: Inhibitors of Grb2-Shc interaction, isolated from Penicillium multicolor F1753: N. Ji-Youn, et al.; J. Microbiol. Biotechnol. 10, 544 (2000)
- Sclerotiorin, from Penicillium frequentans, a potent inhibitor of aldose reductase: C. Chidananda, et al.; Biotechnol. Lett. 28, 1633 (2006)
- Sclerotiorin, a novel inhibitor of lipoxygenase from Penicillium frequentans: C. Chidananda & A.P. Sattur; J. Agric. Food. Chem. 55, 2879 (2007)
- Antimicrobial properties of sclerotiorin, isocHromophilone VI and pencolide, metabolites from a Brazilian cerrado isolate of Penicillium sclerotiorum van Beyma: E. M.F. Lucas, et al.; Braz. J. Microbiol. 38, 785 (2007)
- Synthesis and antifungal activity of novel sclerotiorin analogues: L. Lin, et al.; J. Agric. Food Chem. 60, 4480 (2012)
- Anticancer activity of sclerotiorin, isolated from an endophytic fungus Cephalotheca faveolata: P. Giridharan, et al.; Indian J. Exp. Biol. 50, 464 (2012)
品牌介绍
Adipogen公司由三个子公司组成，分别是Adipogen,Inc.(韩国),AdipogenSA(瑞士)和 AdipogenCorporation(美国圣地亚哥)。总部设在美国，运营总部在瑞士利斯塔尔。Adipogen公司专门从事生命科学研究试剂的开发，如癌症、免疫、炎症、代谢疾病（糖尿病、肥胖）、干细胞和神经退行性疾病等领域。其重点关注开发创新优质的ELISA试剂盒。另外，也可提供抗体和蛋白产品，Adipogen拥有自己的化学实验室，致力于开发创新型小分子化合物。
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